ID   CDD_HAES1               Reviewed;         303 AA.
AC   Q0I4X6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=HS_1257;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17172329; DOI=10.1128/JB.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni)
RT   strain 129Pt and comparison to Haemophilus ducreyi 35000HP and
RT   Haemophilus influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; CP000436; ABI25532.1; -; Genomic_DNA.
DR   RefSeq; YP_719469.1; -.
DR   GeneID; 4240768; -.
DR   GenomeReviews; CP000436_GR; HS_1257.
DR   KEGG; hso:HS_1257; -.
DR   NMPDR; fig|205914.1.peg.908; -.
DR   HOGENOM; Q0I4X6; -.
DR   OMA; Q0I4X6; FSPCGHC.
DR   BioCyc; HSOM205914:HS_1257-MON; -.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046087; P:cytidine metabolic process; IEA:InterPro.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR006263; Cyt_deam_dimer.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   TIGRFAMs; TIGR01355; cyt_deam_dimer; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    303       Cytidine deaminase.
FT                                /FTId=PRO_0000318623.
FT   REGION       98    100       Substrate binding (By similarity).
FT   ACT_SITE    113    113       Proton donor (By similarity).
FT   METAL       111    111       Zinc; catalytic (By similarity).
FT   METAL       138    138       Zinc; catalytic (By similarity).
FT   METAL       141    141       Zinc; catalytic (By similarity).
SQ   SEQUENCE   303 AA;  34347 MW;  16CDCC47C9A6B43F CRC64;
     MTHHSLKHIS DRIKQALNQI ENRNLAQDLW YILGEQNFQG FLPAFTVNHF CEKYHMTDKE
     LALILLPVSA CYANPTISHF SVGAIAKGES GSFYFGANQE FCTTNIQQTV HAEQSAISHA
     WMRRESKITE ITVNYTPCGH CRQFMNELNS AETLRIHLPH SQDNLLHHYL PDAFGPHNLQ
     IDNRLFDKKA HNLFFVTEDP LIQAALDAAN QSHAPYSKTY SGIALQLQDQ QIFQGSYAEN
     AAFNPSLPPL QTALNYLLLN GNEVENIARA VLVEQPFRLS YRGMTEELLA YLGDIPLDYI
     QVS
//