Reviewed, UniProtKB/Swiss-Prot Q0I4X6 (CDD_HAES1)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	HS_1257

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Cytidine deaminase HAMAP MF_01558		PRO_0000318623
Regions
	Region	98 – 100	3	Substrate binding By similarity
Sites
	Active site	113	1	Proton donor By similarity
	Metal binding	111	1	Zinc; catalytic By similarity
	Metal binding	138	1	Zinc; catalytic By similarity
	Metal binding	141	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0I4X6-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 16CDCC47C9A6B43F	FASTA	303	34,347
	10 20 30 40 50 60 MTHHSLKHIS DRIKQALNQI ENRNLAQDLW YILGEQNFQG FLPAFTVNHF CEKYHMTDKE 70 80 90 100 110 120 LALILLPVSA CYANPTISHF SVGAIAKGES GSFYFGANQE FCTTNIQQTV HAEQSAISHA 130 140 150 160 170 180 WMRRESKITE ITVNYTPCGH CRQFMNELNS AETLRIHLPH SQDNLLHHYL PDAFGPHNLQ 190 200 210 220 230 240 IDNRLFDKKA HNLFFVTEDP LIQAALDAAN QSHAPYSKTY SGIALQLQDQ QIFQGSYAEN 250 260 270 280 290 300 AAFNPSLPPL QTALNYLLLN GNEVENIARA VLVEQPFRLS YRGMTEELLA YLGDIPLDYI QVS

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000436 Genomic DNA. Translation: ABI25532.1.
RefSeq	YP_719469.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4240768.
GenomeReviews	Gene locus HS_1257 in contig CP000436_GR.
KEGG	hso:HS_1257.
NMPDR	fig|205914.1.peg.908.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0I4X6.
OMA	Q0I4X6. FSPCGHC.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1257-MON.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006263. Cyt_deam_dimer. IPR013171. dC_C_deam_Zn_bd. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_HAES1

Accession

Primary (citable) accession number: Q0I4X6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)