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Q0I4M5

- LPXB_HISS1

UniProt

Q0I4M5 - LPXB_HISS1

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, HS_1358
Organism
Histophilus somni (strain 129Pt) (Haemophilus somnus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-1417-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HS_1358
OrganismiHistophilus somni (strain 129Pt) (Haemophilus somnus)
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000001970: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000072225Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_1358.

Structurei

3D structure databases

ProteinModelPortaliQ0I4M5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0I4M5-1 [UniParc]FASTAAdd to Basket

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MIDKKNITIG IVAGEVSGDI LGAGLIRALK IQYPQARFIG IAGKNMLAEG    50
CKTLVDMEEI AVMGLVEVIK YLPRLLKIRR LVIDTMLAEK PDIFIGIDAP 100
DFNLDIELKL KKQGIKTLHY VSPSVWAWRQ KRIVKIAQAT NLVLAFLPFE 150
KAFYDRFNVP CRFVGHTMAD IIDLQPDRQD ACFQLNLEPK HRYVAILVGS 200
REAEVQFLTP PFLQTAQLIK QRFPDVQFLV PLVNEKRRKQ FEQIKAQIAP 250
HLEVVFLDGQ ARQAMIVAEA SLLASGTASL ECMLCKSPMV VGYKMKPFTY 300
FLAKRLVKTK YISLPNLLAD DMLVPEMIQE DCTAEKLAEK LSVYLEQTES 350
GIKNRQHLIQ QFTQLHQLIR CNADKQAAQA VIDLLNDEV 389
Length:389
Mass (Da):44,048
Last modified:October 3, 2006 - v1
Checksum:i4466C347ECD64153
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000436 Genomic DNA. Translation: ABI25633.1.
RefSeqiYP_719570.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI25633; ABI25633; HS_1358.
GeneIDi4240873.
KEGGihso:HS_1358.
PATRICi20282823. VBIHaeSom53361_1428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000436 Genomic DNA. Translation: ABI25633.1 .
RefSeqi YP_719570.1. NC_008309.1.

3D structure databases

ProteinModelPortali Q0I4M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205914.HS_1358.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI25633 ; ABI25633 ; HS_1358 .
GeneIDi 4240873.
KEGGi hso:HS_1358.
PATRICi 20282823. VBIHaeSom53361_1428.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HSOM205914:GJ7V-1417-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
    Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
    J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129Pt.

Entry informationi

Entry nameiLPXB_HISS1
AccessioniPrimary (citable) accession number: Q0I4M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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