Q0I4D8 (GPMA_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	HS_1445

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus › Haemophilus somnus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular_function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP-Rule MF_01039		PRO_1000064064
Sites
	Active site	8	1	Tele-phosphohistidine intermediate By similarity
	Active site	181	1	By similarity
	Site	59	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0I4D8 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: FFC3CC21130086FA	FASTA	227	26,015
	10 20 30 40 50 60 MELVFIRHGF SEWNAKNLFT GWRDVNLTER GIEEAKAAGK KLLEAGYEFD IAFTSVLTRA 70 80 90 100 110 120 IKTCNIVLEE SNQLWIPQVK HWRLNERHYG ALQGLDKKAT AEQYGDEQVH IWRRSYDVSP 130 140 150 160 170 180 PDLDPQDPNS AHNDRRYALL PKDVVPNAEN LKITLERVLP FWEDQIAPAL LSGKRVLVTA 190 200 210 220 HGNSLRALAK HIIGISDEEI MAFEIPTGQP LVLKLDEQLN FVEKFYL

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25720.1.
RefSeq	YP_719657.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I4D8.
SMR	Q0I4D8. Positions 2-227.
ModBase	Search...
Protein-protein interaction databases
STRING	205914.HS_1445.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABI25720; ABI25720; HS_1445.
GeneID	4240961.
KEGG	hso:HS_1445.
PATRIC	20283009. VBIHaeSom53361_1520.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HOG000221682.
KO	K01834.
OMA	GQSDWNL.
ProtClustDB	PRK14118.
Enzyme and pathway databases
BioCyc	HSOM205914:GJ7V-1505-MONOMER.
UniPathway	UPA00109; UER00186.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA.
InterPro	IPR013078. His_Pase_superF_clade-1. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. PTHR11931. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_HAES1

Accession

Primary (citable) accession number: Q0I4D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program