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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Haemophilus somnus (strain 129Pt) (Histophilus somni)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:HS_1021
OrganismiHaemophilus somnus (strain 129Pt) (Histophilus somni)
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000001970 Componenti: Chromosome

Subcellular locationi

Q0I4C5:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalUniRule annotationAdd BLAST21
Transmembranei65 – 85HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei161 – 181HelicalUniRule annotationAdd BLAST21
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei274 – 294HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716301 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi205914.HS_1021.

Structurei

3D structure databases

ProteinModelPortaliQ0I4C5.
SMRiQ0I4C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 310ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0I4C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDKDLSTLQ TFKRLWPTIA PFKLGLIASA VALVFNALAD AALIQMLKPV
60 70 80 90 100
LDEGFGKVDN SLLRIMAIVV VLLIFVRGVT NFISTYCLAW VSGKVVMVMR
110 120 130 140 150
RRLFRHLMYM PVTFFDQNSV GRLLSRIVYD SEQVANSSSG SLVTIVREGA
160 170 180 190 200
YIIALLTVMF YTSWQLALVL FIIGPIIAVI IRIVSKKFRE LGKNLQNSMG
210 220 230 240 250
DLTSSVEQML KGHKVVLAFG GQKIEEERFD QVSNNMRRRG MKVMAASAIS
260 270 280 290 300
DPVVQIIASF ALAAVLFLAT LPEIMTQNLS AGSFTVVFSS MLAMMRPLKS
310 320 330 340 350
LTNVNAQFQR GMAACQTLFA LLDLETEKDT GKHVVDTVKG EVRFENVTFS
360 370 380 390 400
YSGKEHPALN NISFTIPQGK TVALVGRSGS GKSTIANLVT RFYDVEQGKI
410 420 430 440 450
TLDGVNIQDY TLANLREHCA VVSQQVHLFN DTIANNIAYA VTEKCTREQI
460 470 480 490 500
IEAAEAAYAM EFIEKLENGL DTVIGENGAS LSGGQRQRLA IARALLRDSP
510 520 530 540 550
VLILDEATSA LDTESERAIQ AALETLQKDR TVLVIAHRLS TIEKADEILV
560 570 580
IEQGEIKERG SHQELLALNG AYKQLHSTQF NH
Length:582
Mass (Da):64,216
Last modified:October 3, 2006 - v1
Checksum:iE92AEC7A751DED26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI25296.1.
RefSeqiWP_011609176.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI25296; ABI25296; HS_1021.
KEGGihso:HS_1021.

Similar proteinsi

Entry informationi

Entry nameiMSBA_HAES1
AccessioniPrimary (citable) accession number: Q0I4C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families