ID   NAGK_HAES1              Reviewed;         305 AA.
AC   Q0I4A5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   05-MAY-2009, entry version 21.
DE   RecName: Full=N-acetyl-D-glucosamine kinase;
DE            EC=2.7.1.59;
DE   AltName: Full=GlcNAc kinase;
GN   Name=nagK; OrderedLocusNames=HS_1041;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17172329; DOI=10.1128/JB.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni)
RT   strain 129Pt and comparison to Haemophilus ducreyi 35000HP and
RT   Haemophilus influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetyl-D-glucosamine
CC       (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-
CC       D-glucosamine 6-phosphate.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NagK subfamily.
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DR   EMBL; CP000436; ABI25316.1; -; Genomic_DNA.
DR   RefSeq; YP_719253.1; -.
DR   GeneID; 4240539; -.
DR   GenomeReviews; CP000436_GR; HS_1041.
DR   KEGG; hso:HS_1041; -.
DR   NMPDR; fig|205914.1.peg.608; -.
DR   HOGENOM; Q0I4A5; -.
DR   OMA; Q0I4A5; TALDPHV.
DR   BioCyc; HSOM205914:HS_1041-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0045127; F:N-acetylglucosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:HAMAP.
DR   GO; GO:0009254; P:peptidoglycan turnover; IEA:HAMAP.
DR   HAMAP; MF_01271; -; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    305       N-acetyl-D-glucosamine kinase.
FT                                /FTId=PRO_0000270107.
FT   NP_BIND       4     11       ATP (Potential).
FT   NP_BIND     133    140       ATP (Potential).
FT   METAL       157    157       Zinc (By similarity).
FT   METAL       178    178       Zinc (By similarity).
FT   METAL       180    180       Zinc (By similarity).
FT   METAL       185    185       Zinc (By similarity).
SQ   SEQUENCE   305 AA;  33529 MW;  8A9D05A5D20AFC32 CRC64;
     MYYGFDIGGT KIELAVFNEK LEKRYSERVD TPKHSYDEWL NVITHLVQKA DEKFACKGTV
     GIGVPGFVNQ ETGIAEITNI RVADNKPILK DLSERLGREV RAENDANCFA LSEAWDKDNQ
     QYPVVLGLIL GTGFGGGLVF NGKVHSGQSG MAGELGHLQL NYHALKLLGW DKAPIYECGC
     GNKACLDTYL SGRGFEMLYR DLQGKALSAK EIIRCFYDKD ESAVKFVELF IELCAISIGN
     IITALDPHVI ILGGGLSNFD YLYEALPKAL PQHLMRTAKV PLIKKAKFGD SGGVRGAAAL
     FLSRD
//