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Q0I4A5 (NAGK_HAES1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase

EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:nagK
Ordered Locus Names:HS_1041
OrganismHaemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]
Taxonomic identifier205914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity. HAMAP MF_01271

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. HAMAP MF_01271

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_01271

Sequence similarities

Belongs to the ROK (nagC/xylR) family. NagK subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305N-acetyl-D-glucosamine kinase HAMAP MF_01271
PRO_0000270107

Regions

Nucleotide binding4 – 118ATP Potential
Nucleotide binding133 – 1408ATP Potential

Sites

Metal binding1571Zinc By similarity
Metal binding1781Zinc By similarity
Metal binding1801Zinc By similarity
Metal binding1851Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0I4A5 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 8A9D05A5D20AFC32

FASTA30533,529
        10         20         30         40         50         60 
MYYGFDIGGT KIELAVFNEK LEKRYSERVD TPKHSYDEWL NVITHLVQKA DEKFACKGTV 

        70         80         90        100        110        120 
GIGVPGFVNQ ETGIAEITNI RVADNKPILK DLSERLGREV RAENDANCFA LSEAWDKDNQ 

       130        140        150        160        170        180 
QYPVVLGLIL GTGFGGGLVF NGKVHSGQSG MAGELGHLQL NYHALKLLGW DKAPIYECGC 

       190        200        210        220        230        240 
GNKACLDTYL SGRGFEMLYR DLQGKALSAK EIIRCFYDKD ESAVKFVELF IELCAISIGN 

       250        260        270        280        290        300 
IITALDPHVI ILGGGLSNFD YLYEALPKAL PQHLMRTAKV PLIKKAKFGD SGGVRGAAAL 


FLSRD 

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References

[1]"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129Pt.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000436 Genomic DNA. Translation: ABI25316.1.
RefSeqYP_719253.1. NC_008309.1.

3D structure databases

ProteinModelPortalQ0I4A5.
SMRQ0I4A5. Positions 1-303.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0I4A5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4240539.
GenomeReviewsGene locus HS_1041 in contig CP000436_GR.
KEGGhso:HS_1041.
NMPDRfig|205914.1.peg.608.
PATRIC20282115. VBIHaeSom53361_1090.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1940.
HOGENOMHBG730260.
OMACAISIGN.
PhylomeDBQ0I4A5.
ProtClustDBPRK13310.

Enzyme and pathway databases

BioCycHSOM205914:HS_1041-MONOMER.

Family and domain databases

HAMAPMF_01271. GlcNAc_kinase.
[Tree]
InterProIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
KOK00884.
PfamPF00480. ROK. 1 hit.
[Graphical view]
PROSITEPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGK_HAES1
AccessionPrimary (citable) accession number: Q0I4A5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families