Q0I4A5 (NAGK_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-D-glucosamine kinase
EC=2.7.1.59

Alternative name(s):
GlcNAc kinase

Gene names

Name:	nagK
Ordered Locus Names:	HS_1041

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity. HAMAP MF_01271
Catalytic activity	ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. HAMAP MF_01271
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_01271
Sequence similarities	Belongs to the ROK (nagC/xylR) family. NagK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW N-acetylglucosamine kinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	N-acetyl-D-glucosamine kinase HAMAP MF_01271		PRO_0000270107
Regions
	Nucleotide binding	4 – 11	8	ATP Potential
	Nucleotide binding	133 – 140	8	ATP Potential
Sites
	Metal binding	157	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Metal binding	180	1	Zinc By similarity
	Metal binding	185	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0I4A5 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 8A9D05A5D20AFC32	FASTA	305	33,529
	10 20 30 40 50 60 MYYGFDIGGT KIELAVFNEK LEKRYSERVD TPKHSYDEWL NVITHLVQKA DEKFACKGTV 70 80 90 100 110 120 GIGVPGFVNQ ETGIAEITNI RVADNKPILK DLSERLGREV RAENDANCFA LSEAWDKDNQ 130 140 150 160 170 180 QYPVVLGLIL GTGFGGGLVF NGKVHSGQSG MAGELGHLQL NYHALKLLGW DKAPIYECGC 190 200 210 220 230 240 GNKACLDTYL SGRGFEMLYR DLQGKALSAK EIIRCFYDKD ESAVKFVELF IELCAISIGN 250 260 270 280 290 300 IITALDPHVI ILGGGLSNFD YLYEALPKAL PQHLMRTAKV PLIKKAKFGD SGGVRGAAAL FLSRD

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25316.1.
RefSeq	YP_719253.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I4A5.
SMR	Q0I4A5. Positions 1-303.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I4A5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4240539.
GenomeReviews	Gene locus HS_1041 in contig CP000436_GR.
KEGG	hso:HS_1041.
NMPDR	fig|205914.1.peg.608.
PATRIC	20282115. VBIHaeSom53361_1090.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1940.
HOGENOM	HBG730260.
OMA	CAISIGN.
PhylomeDB	Q0I4A5.
ProtClustDB	PRK13310.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1041-MONOMER.
Family and domain databases
HAMAP	MF_01271. GlcNAc_kinase. [Tree]
InterPro	IPR023505. N-acetyl-D-glucosamine_kinase. IPR000600. ROK. [Graphical view]
KO	K00884.
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGK_HAES1

Accession

Primary (citable) accession number: Q0I4A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program