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Q0I4A5

- NAGK_HISS1

UniProt

Q0I4A5 - NAGK_HISS1

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Histophilus somni (strain 129Pt) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-1080-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:HS_1041
OrganismiHistophilus somni (strain 129Pt) (Haemophilus somnus)
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000001970: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305N-acetyl-D-glucosamine kinasePRO_0000270107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_1041.

Structurei

3D structure databases

ProteinModelPortaliQ0I4A5.
SMRiQ0I4A5. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0I4A5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGFDIGGT KIELAVFNEK LEKRYSERVD TPKHSYDEWL NVITHLVQKA
60 70 80 90 100
DEKFACKGTV GIGVPGFVNQ ETGIAEITNI RVADNKPILK DLSERLGREV
110 120 130 140 150
RAENDANCFA LSEAWDKDNQ QYPVVLGLIL GTGFGGGLVF NGKVHSGQSG
160 170 180 190 200
MAGELGHLQL NYHALKLLGW DKAPIYECGC GNKACLDTYL SGRGFEMLYR
210 220 230 240 250
DLQGKALSAK EIIRCFYDKD ESAVKFVELF IELCAISIGN IITALDPHVI
260 270 280 290 300
ILGGGLSNFD YLYEALPKAL PQHLMRTAKV PLIKKAKFGD SGGVRGAAAL

FLSRD
Length:305
Mass (Da):33,529
Last modified:October 3, 2006 - v1
Checksum:i8A9D05A5D20AFC32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI25316.1.
RefSeqiWP_011609196.1. NC_008309.1.
YP_719253.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI25316; ABI25316; HS_1041.
GeneIDi4240539.
KEGGihso:HS_1041.
PATRICi20282115. VBIHaeSom53361_1090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI25316.1 .
RefSeqi WP_011609196.1. NC_008309.1.
YP_719253.1. NC_008309.1.

3D structure databases

ProteinModelPortali Q0I4A5.
SMRi Q0I4A5. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205914.HS_1041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI25316 ; ABI25316 ; HS_1041 .
GeneIDi 4240539.
KEGGi hso:HS_1041.
PATRICi 20282115. VBIHaeSom53361_1090.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci HSOM205914:GJ7V-1080-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
    Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
    J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129Pt.

Entry informationi

Entry nameiNAGK_HISS1
AccessioniPrimary (citable) accession number: Q0I4A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3