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Q0I4A5

- NAGK_HISS1

UniProt

Q0I4A5 - NAGK_HISS1

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Protein
N-acetyl-D-glucosamine kinase
Gene
nagK, HS_1041
Organism
Histophilus somni (strain 129Pt) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571Zinc By similarity
Metal bindingi178 – 1781Zinc By similarity
Metal bindingi180 – 1801Zinc By similarity
Metal bindingi185 – 1851Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATP Reviewed prediction
Nucleotide bindingi133 – 1408ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-1080-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Ordered Locus Names:HS_1041
OrganismiHistophilus somni (strain 129Pt) (Haemophilus somnus)
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000001970: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305N-acetyl-D-glucosamine kinaseUniRule annotation
PRO_0000270107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_1041.

Structurei

3D structure databases

ProteinModelPortaliQ0I4A5.
SMRiQ0I4A5. Positions 1-303.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0I4A5-1 [UniParc]FASTAAdd to Basket

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MYYGFDIGGT KIELAVFNEK LEKRYSERVD TPKHSYDEWL NVITHLVQKA    50
DEKFACKGTV GIGVPGFVNQ ETGIAEITNI RVADNKPILK DLSERLGREV 100
RAENDANCFA LSEAWDKDNQ QYPVVLGLIL GTGFGGGLVF NGKVHSGQSG 150
MAGELGHLQL NYHALKLLGW DKAPIYECGC GNKACLDTYL SGRGFEMLYR 200
DLQGKALSAK EIIRCFYDKD ESAVKFVELF IELCAISIGN IITALDPHVI 250
ILGGGLSNFD YLYEALPKAL PQHLMRTAKV PLIKKAKFGD SGGVRGAAAL 300
FLSRD 305
Length:305
Mass (Da):33,529
Last modified:October 3, 2006 - v1
Checksum:i8A9D05A5D20AFC32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000436 Genomic DNA. Translation: ABI25316.1.
RefSeqiWP_011609196.1. NC_008309.1.
YP_719253.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI25316; ABI25316; HS_1041.
GeneIDi4240539.
KEGGihso:HS_1041.
PATRICi20282115. VBIHaeSom53361_1090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000436 Genomic DNA. Translation: ABI25316.1 .
RefSeqi WP_011609196.1. NC_008309.1.
YP_719253.1. NC_008309.1.

3D structure databases

ProteinModelPortali Q0I4A5.
SMRi Q0I4A5. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205914.HS_1041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI25316 ; ABI25316 ; HS_1041 .
GeneIDi 4240539.
KEGGi hso:HS_1041.
PATRICi 20282115. VBIHaeSom53361_1090.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci HSOM205914:GJ7V-1080-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
    Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
    J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129Pt.

Entry informationi

Entry nameiNAGK_HISS1
AccessioniPrimary (citable) accession number: Q0I4A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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