Q0I463 (MUTL_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	HS_1083

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_1000010023

Sequences

	Sequence		Length	Mass (Da)
	Q0I463 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 27DB252823627BA3	FASTA	615	70,295
	10 20 30 40 50 60 MTIKILPPQL ANQIAAGEVV ERPASVVKEL IENSLDAGAT HIQIEIENGG ANLIRIRDNG 70 80 90 100 110 120 IGIAKDELHL ALARHATSKI ASLDDLEMIL SLGFRGEALA SISSVSRLTL TSRTAQQNEA 130 140 150 160 170 180 WQVYAQGRDM ETSITPASHP IGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL 190 200 210 220 230 240 AKPQVAFTLT HNNKLIHRYK SAVTNEQKIK RIATICGNDF MQNALHIDWK HNDLHLSGWV 250 260 270 280 290 300 IQPQFARHQN DLNYCYINGR MVRDKVITHA IRQAYSEYLN NEQYPAFVLF IDLNPNEVDV 310 320 330 340 350 360 NVHPTKHEVR FHQARLIHDF IYQGMTNALT SEQTNIPIQS EQSNPTKVAE PQGIWNLTTH 370 380 390 400 410 420 NKGNRATAGK NIFAQQPKDY DKKSSQFKPH FTANYSEVTP KKAVQKAYAE LLVTHEEKTI 430 440 450 460 470 480 ASSTLPHQFT HNATYISEQK NVLHALALIE NKALLLQQNQ QYFLLSIQAL QHFNIRLQLQ 490 500 510 520 530 540 QSNIAQQTLL IPILLRLNKQ QYQSWQQQAL FFQQSGFDFT ENSAQHRITL NRLPICLRTQ 550 560 570 580 590 600 NIQKIILHLL DQPHEKYTIF LTALCSQLEF PSLSTFSEAV NLLTKTEQQF STQHQPEFQS 610 LLVKIEWDHY LDKLQ

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25358.1.
RefSeq	YP_719295.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I463.
SMR	Q0I463. Positions 1-329.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I463.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4240583.
GenomeReviews	Gene locus HS_1083 in contig CP000436_GR.
KEGG	hso:HS_1083.
NMPDR	fig|205914.1.peg.566.
PATRIC	20282209. VBIHaeSom53361_1136.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HBG520262.
OMA	EVANLFF.
PhylomeDB	Q0I463.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1083-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_HAES1

Accession

Primary (citable) accession number: Q0I463

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program