Reviewed, UniProtKB/Swiss-Prot Q0I414 (NAGZ_HAES1)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	HS_1132

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Beta-hexosaminidase HAMAP MF_00364		PRO_1000005655
Sites
	Active site	249	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0I414-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 7304D5BA829F4960	FASTA	351	40,356
	10 20 30 40 50 60 MSILLIDLSS QELRQEEIEL LEHPLVAGLI LFSRNFYDIE QIRHLIRSVR QKVKKPLLIT 70 80 90 100 110 120 VDQEGGRVQR FRQGFTQLPA MQSFACLLSD PQEQQEMAWR AGWQMAAEMT ALDIDLSFAP 130 140 150 160 170 180 VLDLGHQCKA IGDRSFHYEE KKLIELAEKF IQGMRQIGMS ATGKHFPGHG HVLADSHLET 190 200 210 220 230 240 PYDDRAKELI FAQDIRPFQS LIKQGLLDAV MPAHVIYTQC DNQPASGSSY WLKEVLRQQL 250 260 270 280 290 300 GFQGAIFSDD LGMKGAGFMG DFVARCTQSL QAGCDLLLLC NEPEAVVQVL DRFKPQESQN 310 320 330 340 350 KRIIRQTRLN KLFKKQRIDW QTLRNQRDWL ENHKKLTALQ QDWLAYKGYD N

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000436 Genomic DNA. Translation: ABI25407.1.
RefSeq	YP_719344.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I414.
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Genome annotation databases
GeneID	4240633.
GenomeReviews	Gene locus HS_1132 in contig CP000436_GR.
KEGG	hso:HS_1132.
NMPDR	fig|205914.1.peg.427.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0I414.
OMA	WQYMANT.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1132-MON.
Family and domain databases
HAMAP	MF_00364. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_HAES1

Accession

Primary (citable) accession number: Q0I414

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)