Q0I3Y4 (UBIG_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-demethylubiquinone-9 3-methyltransferase
EC=2.1.1.64

Alternative name(s):
2-polyprenyl-6-hydroxyphenyl methylase
EC=2.1.1.222
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
Short name=DHHB methyltransferase

Gene names

Name:	ubiG
Ordered Locus Names:	HS_1162

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Non-specific O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway By similarity.
Catalytic activity	S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. HAMAP MF_00472 S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_00472
Sequence similarities	Belongs to the methyltransferase superfamily. UbiG/COQ3 family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Inferred from electronic annotation. Source: InterPro 3-demethylubiquinone-9 3-O-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	3-demethylubiquinone-9 3-methyltransferase HAMAP MF_00472		PRO_1000013902

Sequences

	Sequence		Length	Mass (Da)
	Q0I3Y4 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 636BC7350AE61CD7	FASTA	238	27,028
	10 20 30 40 50 60 MQNLDPQELE KFEKMAKSWW DPNGDFKPIH QLNPTRLQYI QQQANGLTEK KVLDVGCGGG 70 80 90 100 110 120 ILSEAMAKQG AIVTGIDMTV APLEVARLHA KEQGLVIDYQ QITVEEFLQK QTALYAEKFD 130 140 150 160 170 180 VITCMEMLEH VPDPLSIIQS CRALLKPNGV LFFSTINHTF KAWALVVLGA EYILKMLPKG 190 200 210 220 230 THDYDKFIKP AELLHWTDQA NLVCKNICGY HYNLLTGKFW LNQDVSANYM ATFQHKSI

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25437.1.
RefSeq	YP_719374.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I3Y4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I3Y4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4240663.
GenomeReviews	Gene locus HS_1162 in contig CP000436_GR.
KEGG	hso:HS_1162.
NMPDR	fig|205914.1.peg.458.
PATRIC	20282373. VBIHaeSom53361_1217.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2227.
HOGENOM	HBG738842.
OMA	DHAEIAK.
PhylomeDB	Q0I3Y4.
ProtClustDB	PRK05134.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1162-MONOMER.
Family and domain databases
HAMAP	MF_00472. UbiG. [Tree]
InterPro	IPR013216. Methyltransf_11. IPR010233. UbiG_MeTrfase. [Graphical view]
KO	K00568.
PANTHER	PTHR23134. PTHR23134. 1 hit.
Pfam	PF08241. Methyltransf_11. 1 hit. [Graphical view]
TIGRFAMs	TIGR01983. UbiG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UBIG_HAES1

Accession

Primary (citable) accession number: Q0I3Y4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program