Reviewed, UniProtKB/Swiss-Prot Q0I3D2 (PDXY_HAES1)

Names and origin

Protein names

Recommended name:
    Pyridoxamine kinase
      Short name=PM kinase
    EC=2.7.1.35

Gene names

Name:	pdxY
Ordered Locus Names:	HS_0933

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine By similarity.
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01639
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP pyridoxine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP pyridoxal kinase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Pyridoxamine kinase HAMAP MF_01639		PRO_0000269812
Regions
	Nucleotide binding	181 – 182	2	ATP By similarity
Sites
	Binding site	9	1	Substrate By similarity
	Binding site	44	1	Substrate By similarity
	Binding site	222	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0I3D2-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 1846ACBCAC5A3ECC	FASTA	286	31,347
	10 20 30 40 50 60 MKNILSIQSH VVYGYAGNKS ATFPMQLLGI DVWALNTVQF SNHTQYGKWT GMVIPKEQIG 70 80 90 100 110 120 EIVQGIDNIG ELHQCDAVLS GYIGSAEQVE EIIKAFHKIK ERNPKAIYLC DPVMGHPDKG 130 140 150 160 170 180 CVVADGVKEG LIKIAMAQAD IITPNLVELR ELSGLAVENF EQAIEAVKVI LSKGPKKVLV 190 200 210 220 230 240 KHLSRVGKNA AQFEMLLANN DGIWHISRPL HNFNKEPVGV GDLTAGLFLA NLLNGKSDVE 250 260 270 280 AFEHTANTVN DVMETTHNAG VYELQTIAAR EWIVNPKSQY KAVKIG

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000436 Genomic DNA. Translation: ABI25208.1.
RefSeq	YP_719144.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4240426.
GenomeReviews	Gene locus HS_0933 in contig CP000436_GR.
KEGG	hso:HS_0933.
NMPDR	fig|205914.1.peg.1082.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0I3D2.
OMA	Q0I3D2. EVLLETQ.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_0933-MON.
Family and domain databases
HAMAP	MF_01639. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. [Graphical view]
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXY_HAES1

Accession

Primary (citable) accession number: Q0I3D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)