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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Haemophilus somnus (strain 129Pt) (Histophilus somni)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileUniRule annotation1
Metal bindingi10MagnesiumUniRule annotation1
Metal bindingi12MagnesiumUniRule annotation1
Metal bindingi176MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processCarbohydrate metabolismUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotationImported
Ordered Locus Names:HS_0176Imported
OrganismiHaemophilus somnus (strain 129Pt) (Histophilus somni)Imported
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000001970 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_0176.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HSZX-ray1.90A/B1-224[»]
ProteinModelPortaliQ0I1W8.
SMRiQ0I1W8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0I1W8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 193HAD-like_domInterPro annotationAdd BLAST185

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiYLCGKFG.
OrthoDBiPOG091H010N.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
PfamiView protein in Pfam
PF13419. HAD_2. 1 hit.
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0I1W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFKLIGFD LDGTLVNSLP DLALSINSAL KDVNLPQASE NLVMTWIGNG
60 70 80 90 100
ADVLSQRAVD WACKQAEKEL TEDEFKYFKR QFGFYYGENL CNISRLYPNV
110 120 130 140 150
KETLEALKAQ GYILAVVTNK PTKHVQPILT AFGIDHLFSE MLGGQSLPEI
160 170 180 190 200
KPHPAPFYYL CGKFGLYPKQ ILFVGDSQND IFAAHSAGCA VVGLTYGYNY
210 220
NIPIAQSKPD WIFDDFADIL KITQ
Length:224
Mass (Da):25,030
Last modified:October 3, 2006 - v1
Checksum:i68AA88D6E54277A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI24454.1.
RefSeqiWP_011608329.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI24454; ABI24454; HS_0176.
KEGGihso:HS_0176.

Similar proteinsi

Entry informationi

Entry nameiQ0I1W8_HAES1
AccessioniPrimary (citable) accession number: Q0I1W8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported