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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Haemophilus somnus (strain 129Pt) (Histophilus somni)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101NucleophileUniRule annotation
Metal bindingi10 – 101MagnesiumUniRule annotation
Metal bindingi12 – 121MagnesiumUniRule annotation
Metal bindingi176 – 1761MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Carbohydrate metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-182-MONOMER.
UniPathwayiUPA00865; UER00834.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotationImported
Ordered Locus Names:HS_0176Imported
OrganismiHaemophilus somnus (strain 129Pt) (Histophilus somni)Imported
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000001970 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_0176.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HSZX-ray1.90A/B1-224[»]
ProteinModelPortaliQ0I1W8.
SMRiQ0I1W8. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0I1W8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 193185HAD-like_domInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OrthoDBiEOG6HB9PJ.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR000150. Hypothet_cof.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.
PROSITEiPS01228. COF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0I1W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFKLIGFD LDGTLVNSLP DLALSINSAL KDVNLPQASE NLVMTWIGNG
60 70 80 90 100
ADVLSQRAVD WACKQAEKEL TEDEFKYFKR QFGFYYGENL CNISRLYPNV
110 120 130 140 150
KETLEALKAQ GYILAVVTNK PTKHVQPILT AFGIDHLFSE MLGGQSLPEI
160 170 180 190 200
KPHPAPFYYL CGKFGLYPKQ ILFVGDSQND IFAAHSAGCA VVGLTYGYNY
210 220
NIPIAQSKPD WIFDDFADIL KITQ
Length:224
Mass (Da):25,030
Last modified:October 3, 2006 - v1
Checksum:i68AA88D6E54277A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI24454.1.
RefSeqiWP_011608329.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI24454; ABI24454; HS_0176.
KEGGihso:HS_0176.
PATRICi20280260. VBIHaeSom53361_0188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI24454.1.
RefSeqiWP_011608329.1. NC_008309.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HSZX-ray1.90A/B1-224[»]
ProteinModelPortaliQ0I1W8.
SMRiQ0I1W8. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205914.HS_0176.

Protocols and materials databases

DNASUi4239687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI24454; ABI24454; HS_0176.
KEGGihso:HS_0176.
PATRICi20280260. VBIHaeSom53361_0188.

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OrthoDBiEOG6HB9PJ.

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.
BioCyciHSOM205914:GJ7V-182-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ0I1W8.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR000150. Hypothet_cof.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.
PROSITEiPS01228. COF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Crystal structure of novel predicted phosphatase from Haemophilus somnus 129PT at 1.90 A resolution."
    Joint Center for Structural Genomics (JCSG)
    Submitted (JUL-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
  2. "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
    Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
    J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129PtImported.

Entry informationi

Entry nameiQ0I1W8_HAES1
AccessioniPrimary (citable) accession number: Q0I1W8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.