ID   COAA_HAES1              Reviewed;         317 AA.
AC   Q0I1U8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaA; OrderedLocusNames=HS_0196;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17172329; DOI=10.1128/JB.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni)
RT   strain 129Pt and comparison to Haemophilus ducreyi 35000HP and
RT   Haemophilus influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme
CC       A from pantothenate: step 1/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the prokaryotic pantothenate kinase family.
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DR   EMBL; CP000436; ABI24474.1; -; Genomic_DNA.
DR   RefSeq; YP_718403.1; -.
DR   GeneID; 4239711; -.
DR   GenomeReviews; CP000436_GR; HS_0196.
DR   KEGG; hso:HS_0196; -.
DR   HOGENOM; Q0I1U8; -.
DR   OMA; Q0I1U8; PKVDLIT.
DR   BioCyc; HSOM205914:HS_0196-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004594; F:pantothenate kinase activity; IEA:HAMAP.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00215; -; 1.
DR   InterPro; IPR004566; PanK_bact.
DR   PANTHER; PTHR10285:SF7; PanK_bact; 1.
DR   PIRSF; PIRSF000545; Pantothenate_kin; 1.
DR   TIGRFAMs; TIGR00554; panK_bact; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    317       Pantothenate kinase.
FT                                /FTId=PRO_1000043217.
FT   NP_BIND      99    106       ATP (Potential).
SQ   SEQUENCE   317 AA;  36743 MW;  F5F307A73182F955 CRC64;
     MEELNTIKLS DHLTPFLTFN RQQWAELRKS VPLKLTEQDL KPLLGFNEEL SLEEVSTIYL
     PLARLINYYI EENLRRQTVL KRFLSGHNPK VPYIISIAGS VSVGKSTSAR ILQSLLANWP
     VARKVDLITT DGFLYPLEIL QKKNLLQKKG FPISYDTQRL IRFLADIKSG KKNVKAPIYS
     HLTYDIIPNQ FDIVDRPDIL ILEGLNVLQI GTNKSNQMFV SDFVDFSIFV DAEEDQLKEW
     YIKRFLKFCR SAFTDPNSYF KHYANLSEQE AIETASQIWD NINGLNLKQN ILPTRERANL
     ILKKGENHKV ELVKLRK
//