Q0I1U8 (COAA_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	HS_0196

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Pantothenate kinase HAMAP MF_00215		PRO_1000043217
Regions
	Nucleotide binding	99 – 106	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0I1U8 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: F5F307A73182F955	FASTA	317	36,743
	10 20 30 40 50 60 MEELNTIKLS DHLTPFLTFN RQQWAELRKS VPLKLTEQDL KPLLGFNEEL SLEEVSTIYL 70 80 90 100 110 120 PLARLINYYI EENLRRQTVL KRFLSGHNPK VPYIISIAGS VSVGKSTSAR ILQSLLANWP 130 140 150 160 170 180 VARKVDLITT DGFLYPLEIL QKKNLLQKKG FPISYDTQRL IRFLADIKSG KKNVKAPIYS 190 200 210 220 230 240 HLTYDIIPNQ FDIVDRPDIL ILEGLNVLQI GTNKSNQMFV SDFVDFSIFV DAEEDQLKEW 250 260 270 280 290 300 YIKRFLKFCR SAFTDPNSYF KHYANLSEQE AIETASQIWD NINGLNLKQN ILPTRERANL 310 ILKKGENHKV ELVKLRK

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI24474.1.
RefSeq	YP_718403.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I1U8.
SMR	Q0I1U8. Positions 13-317.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I1U8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4239711.
GenomeReviews	Gene locus HS_0196 in contig CP000436_GR.
KEGG	hso:HS_0196.
PATRIC	20280308. VBIHaeSom53361_0208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q0I1U8.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_0196-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_HAES1

Accession

Primary (citable) accession number: Q0I1U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program