ID   Q0I179_HISS1            Unreviewed;       836 AA.
AC   Q0I179;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:ABI24324.1};
GN   OrderedLocusNames=HS_0043 {ECO:0000313|EMBL:ABI24324.1};
OS   Histophilus somni (strain 129Pt) (Haemophilus somnus).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914 {ECO:0000313|EMBL:ABI24324.1};
RN   [1] {ECO:0000313|EMBL:ABI24324.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129PT {ECO:0000313|EMBL:ABI24324.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA   Dalin E., Tice H., Pitluck S., Brettin T.S., Bruce D., Challacombe J.F.,
RA   Chertkov O., Detter J.C., Gilna P., Han S., Misra M., Tapia R.,
RA   Thayer N.N., Xie G., Inzana T.J., Duncan A.J., Siddaramppa S.,
RA   Richardson P.;
RT   "Complete genome sequence of Haemophilus somnus 129PT.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; CP000436; ABI24324.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0I179; -.
DR   KEGG; hso:HS_0043; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          5..207
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   836 AA;  97460 MW;  7F915135DA588042 CRC64;
     MKYDLQQAKK QVEFVDQLRL ERALSSTSVE FQRVLQLLTL LLHINHPLMG GYLPNAPHGI
     ARFQLSKYQQ EFLTTHLPQG DFEQLSTHLA ALQHLTDTPI LGVYVMGSIG SISQTPSSDL
     DIWVCHREDL SLEDKEQLSK KNYLLQQWAR SLGVEINLYL IDQQRFRSFR YADALTSENS
     GSAQYMLLLE EFYRSVIRLA GKPLLWLHLK VANEQDYSSE VNRLIKTKQI NIDDWVDFGC
     LSAFSANEYF GASLWQLYKG IDSPYKSVLK ILLLESYSYE YPNTHLIAQE FKQRLLNNDL
     DYHYDPYLAM LERVSSFLTK LNEFKRLDFV RRCFYMKASE YIVQQQENNW RSKKLHQLTQ
     QWNWSDNLLQ NLNQRTTWKI KKVKESHNDL MQYLMLSYRN LINFGRKHNV NASIMPQDVS
     ILTRKLYTAF EELPGKITLL NQAISLDLSE PHLTFIEVKQ NKFFKAGWYL VTQKPDVQGL
     CQKRHIEYGE NLNKLVSWAY FNGLLTPITS LYIHSDTVSL KTLRNFVADL RLSFPITRTK
     KATNKELTQQ CKIKHLSVTI NLTNDPTAHL LQSKSTILPS DLFSFGPSEE SLVGSIDLTY
     RNIWNEIRTL HFEGANAILL ALKVLSNKIY PGSTPPKSIN VFCYSQHYQK TLCNIVHALI
     KKYIDIRIGD TDAPKNNMLR IAGKNWQLFF EERGLSLQEM QNTSINNSVF DNELRNTIEE
     KETALLAEQK HYPYEMDAFA SEGFLQFFFE DNEDKSFNVY ILDEQNHIEI YRHCEGSKEQ
     KIREINQIYQ SASLDKNNNP YKIVQHNFNY PQFYQLLPDC NGGTKIVPFH SRLALS
//