ID   THIM_HAES1              Reviewed;         266 AA.
AC   Q0I129;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Hydroxyethylthiazole kinase;
DE            EC=2.7.1.50;
DE   AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase;
DE            Short=Thz kinase;
DE            Short=TH kinase;
GN   Name=thiM; OrderedLocusNames=HS_0092;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17172329; DOI=10.1128/JB.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni)
RT   strain 129Pt and comparison to Haemophilus ducreyi 35000HP and
RT   Haemophilus influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-methyl-5-(2-hydroxyethyl)thiazole =
CC       ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine pyrophosphate
CC       biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 4-methyl-
CC       5-(2-hydroxyethyl)-thiazole: step 1/1.
CC   -!- SIMILARITY: Belongs to the Thz kinase family.
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DR   EMBL; CP000436; ABI24373.1; -; Genomic_DNA.
DR   RefSeq; YP_718299.1; -.
DR   GeneID; 4239601; -.
DR   GenomeReviews; CP000436_GR; HS_0092.
DR   KEGG; hso:HS_0092; -.
DR   NMPDR; fig|205914.1.peg.1251; -.
DR   HOGENOM; Q0I129; -.
DR   OMA; Q0I129; ASPVMAH.
DR   BioCyc; HSOM205914:HS_0092-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004417; F:hydroxyethylthiazole kinase activity; IEA:HAMAP.
DR   GO; GO:0009228; P:thiamin biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00228; -; 1.
DR   InterPro; IPR000417; Hyethyz_kinase.
DR   InterPro; IPR011144; Hyethyz_kinsmonf.
DR   PANTHER; PTHR20857:SF14; Hyethyz_kinase; 1.
DR   Pfam; PF02110; HK; 1.
DR   PIRSF; PIRSF000513; Thz_kinase; 1.
DR   PRINTS; PR01099; HYETHTZKNASE.
DR   TIGRFAMs; TIGR00694; thiM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Thiamine biosynthesis; Transferase.
FT   CHAIN         1    266       Hydroxyethylthiazole kinase.
FT                                /FTId=PRO_0000336560.
FT   BINDING      41     41       Substrate; via amide nitrogen (By
FT                                similarity).
FT   BINDING     117    117       ATP (By similarity).
FT   BINDING     163    163       ATP (By similarity).
FT   BINDING     190    190       Substrate; via amide nitrogen (By
FT                                similarity).
SQ   SEQUENCE   266 AA;  28152 MW;  CE24FC71334828B8 CRC64;
     MNSQFLTKLR QRNPLIHNIT NIVAANFSAN GLLAIGASPI MSACIEEMEE MAKLSQSLVI
     NIGTLTGKDV EAMLLAGKTA NQVGIPVVLD PVGVGATTFR QKTTALLLEQ VQFSAIRGNA
     GELAYIAGVQ WSTKGVDAGK GMADIAEIAH LVARKYQCIA VISGETDYIS DGKRLAKLNN
     GTPLFPKITA SGCLLSAVCS AFLAVAEQKD YFDALVEGCS AYAIAGEIAA QSLSSTQFGQ
     FTLGLLDQLA SLTPEQINQY ARISYE
//