Q0I0U8 (DNAA_SHESR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	Shewmr7_0001

Organism

Shewanella sp. (strain MR-7) [Complete proteome] [HAMAP]

Taxonomic identifier

60481 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048724
Regions
	Nucleotide binding	165 – 172	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0I0U8 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: F2B45F2A65C8DCB5	FASTA	460	52,011
	10 20 30 40 50 60 MAVSLWQQCI GRLQDELSAQ QFSMWIRPLQ AEMDGDTLVL YAPNRFVLDW VRDKYINIIN 70 80 90 100 110 120 QFFTEQMGND APKLRFDIGS RPSAKKPEPA PVAAVRVPNP QTKASVGTSF NTTEPVVNAN 130 140 150 160 170 180 HRSNINPTYQ FDNFVEGKSN QLGKAAALQV AENPGGAYNP LFLYGGTGLG KTHLLHAVGN 190 200 210 220 230 240 GIIKNNPNAK VVYMHSERFV QDMVKALQNN AIEEFKRYYR SVDALFIDDI QFFANKDRSQ 250 260 270 280 290 300 EEFFHTFNAL LEGNHQIILT SDRYPKEIDG VEDRLKSRFG WGLTVAIEPP ELETRVAILM 310 320 330 340 350 360 RKAQESGINL PDEVAFFIAK RLRSNVRELE GALNRVIANA NFTGRPITID FVREALRDLL 370 380 390 400 410 420 ALQEKLVTID NIQKTVAEYY KIKMADMLSK RRSRSVARPR QVAMALSKEL TNQSLPEIGD 430 440 450 460 AFGGRDHTTV LHACRKIAQL REESHDIKED YANLIRTLSS

References

[1]

"Complete sequence of chromosome 1 of Shewanella sp. MR-7." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000444 Genomic DNA. Translation: ABI41007.1.
RefSeq	YP_736064.1. NC_008322.1.
3D structure databases
ProteinModelPortal	Q0I0U8.
SMR	Q0I0U8. Positions 2-98, 367-460.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I0U8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4258034.
GenomeReviews	Gene locus Shewmr7_0001 in contig CP000444_GR.
KEGG	shm:Shewmr7_0001.
NMPDR	fig|60481.10.peg.1.
PATRIC	23584810. VBISheSp85603_0009.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	DEVAFLI.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_SHESR

Accession

Primary (citable) accession number: Q0I0U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program