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Q0I060 (ARLY_SHESR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Shewmr7_0240
OrganismShewanella sp. (strain MR-7) [Complete proteome] [HAMAP]
Taxonomic identifier60481 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_1000000542

Sequences

Sequence LengthMass (Da)Tools
Q0I060 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 012141B38F083908

FASTA45549,017
        10         20         30         40         50         60 
MALWGGRFQG ETSALFKLFN DSLPVDYRLF EQDVVGSIAW ADAIASVGII TATECSDLKK 

        70         80         90        100        110        120 
ALNELLVEVK GDPAIILASG AEDIHSFVES ALIAKVGDLG KKLHTGRSRN DQVATDLKLW 

       130        140        150        160        170        180 
CQSEGAALVA RLQTLRSELI ALAEREFDAV MPGYTHLQRA QPVTFGHWCL AYVEMIERDL 

       190        200        210        220        230        240 
SRLTDALKRA NTCPLGSGAL AGTAYQMDRH SLAVALNFAS PTLNSLDSVS DRDHVVELCG 

       250        260        270        280        290        300 
AASISMMHLS RMAEDLIFFN SGEAGFISLS DEVTSGSSLM PQKKNPDALE LIRGKTGRVY 

       310        320        330        340        350        360 
GSLVGILTTM KALPLAYNKD MQEDKEGLFD VVDSWAICLD MAALVLSGLV VNRPNALLAA 

       370        380        390        400        410        420 
QQGYANATEL ADYLVSKGMP FREAHHVVGV AVVAAIAKKI PLEAFSLAEF RTFADIIEAD 

       430        440        450 
VYPNLTIEAC LAKRDVLGGT ALTQVKQAIA AKKVI

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. MR-7."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MR-7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000444 Genomic DNA. Translation: ABI41245.1.
RefSeqYP_736302.1. NC_008322.1.

3D structure databases

ProteinModelPortalQ0I060.
SMRQ0I060. Positions 3-450.
ModBaseSearch...

Protein-protein interaction databases

STRING60481.Shewmr7_0240.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI41245; ABI41245; Shewmr7_0240.
GeneID4256070.
KEGGshm:Shewmr7_0240.
PATRIC23585336. VBISheSp85603_0256.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMAKEGIFDA.
ProtClustDBPRK04833.

Enzyme and pathway databases

UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_SHESR
AccessionPrimary (citable) accession number: Q0I060
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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