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Q0HZP7 (UBIE_SHESR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

EC=2.1.1.163
EC=2.1.1.201
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase
Gene names
Name:ubiE
Ordered Locus Names:Shewmr7_0405
OrganismShewanella sp. (strain MR-7) [Complete proteome] [HAMAP]
Taxonomic identifier60481 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP-Rule MF_01813

Catalytic activity

A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. HAMAP-Rule MF_01813

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP-Rule MF_01813

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. HAMAP-Rule MF_01813

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01813

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
Ubiquinone biosynthesis
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

ubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE HAMAP-Rule MF_01813
PRO_1000056301

Sequences

Sequence LengthMass (Da)Tools
Q0HZP7 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: E433C97ACB23BE56

FASTA25128,105
        10         20         30         40         50         60 
MSEGESKNTH FGYKTVEADK KADLVAGVFH SVAAKYDIMN DVMSFGIHRF WKRYTIEVSG 

        70         80         90        100        110        120 
ARPGMKVLDL AGGTGDLTAK FSHLVGEKGE VVLADINDSM LKVGRTKLRD RGIVGNVSYV 

       130        140        150        160        170        180 
QANAEALPFP DNHFDIITIA FGLRNVTDKD AALRSMNRVL KPGGKLLVLE FSKPQHELMR 

       190        200        210        220        230        240 
KVYDLYSFKV LPKMGEIITK DADSYEYLAE SIRMHPDQET LKQMMVDAGF EQVDYTNMTD 

       250 
GIVALHRGYK F 

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. MR-7."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MR-7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000444 Genomic DNA. Translation: ABI41408.1.
RefSeqYP_736465.1. NC_008322.1.

3D structure databases

ProteinModelPortalQ0HZP7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING60481.Shewmr7_0405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI41408; ABI41408; Shewmr7_0405.
GeneID4256497.
KEGGshm:Shewmr7_0405.
PATRIC23585693. VBISheSp85603_0424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2226.
HOGENOMHOG000249463.
KOK03183.
OMAIWKRFTI.
OrthoDBEOG6M6JSB.
ProtClustDBCLSK907539.

Enzyme and pathway databases

BioCycSSP60481:GHW6-433-MONOMER.
UniPathwayUPA00079; UER00169.
UPA00232.

Family and domain databases

HAMAPMF_01813. UbiE_methyltran.
InterProIPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIE_SHESR
AccessionPrimary (citable) accession number: Q0HZP7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: March 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways