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Q0HZ28

- GCSP_SHESR

UniProt

Q0HZ28 - GCSP_SHESR

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella sp. (strain MR-7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSSP60481:GHW6-652-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Shewmr7_0624
    OrganismiShewanella sp. (strain MR-7)
    Taxonomic identifieri60481 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001960: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000045614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi60481.Shewmr7_0624.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0HZ28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0HZ28-1 [UniParc]FASTAAdd to Basket

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    MTKQTLTQLE QHDLFLRRHI GPDSSQQQEM LNYVGAESLD DLTAQIVPES    50
    IRLNQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL 100
    RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
    EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
    VGPAHEAVNH ELFGALFQYS NRFGQITDFT DLFAELRAKN VVVTVAADIM 250
    SLVLLKSPGA MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
    IIGVSKDTRG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
    FHGPQGLKTI ASRINRFTDI LAAGLQAKGV SLVNNTWFDT ISIKGLDVAA 400
    VNARALAAEM NLRFDADGIV GVSLDETTLR TDIEALFDVI LGAGHGLDVA 450
    ALDAQIVAQG SQSIPEALVR QDAILSHPTF NRYQSETEMM RYIKRLESKD 500
    LALNYSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFCPL DQAKGYTQLI 550
    EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIRKYHES RGEAHRNICL 600
    IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKAKA AEVAENLSCI 650
    MITYPSTHGV YEESIREICN IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKPGRESDNN 750
    GAVSAAPYGS AGILPISWMY IKLLGSNGLK KSTQTALLNA NYVMKKLSEH 800
    YPVLFRGRND RVAHECIIDL RPIKEASGVT EMDIAKRLND YGFHAPTMSF 850
    PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVEAGE WPADNNPLHN 900
    APHTMADIMD PAFDSRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
    LFCACVPLSD YE 962
    Length:962
    Mass (Da):104,821
    Last modified:October 3, 2006 - v1
    Checksum:iDD6C81EF72BB5A63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000444 Genomic DNA. Translation: ABI41627.1.
    RefSeqiWP_011625125.1. NC_008322.1.
    YP_736684.1. NC_008322.1.

    Genome annotation databases

    EnsemblBacteriaiABI41627; ABI41627; Shewmr7_0624.
    GeneIDi4255821.
    KEGGishm:Shewmr7_0624.
    PATRICi23586141. VBISheSp85603_0648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000444 Genomic DNA. Translation: ABI41627.1 .
    RefSeqi WP_011625125.1. NC_008322.1.
    YP_736684.1. NC_008322.1.

    3D structure databases

    ProteinModelPortali Q0HZ28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 60481.Shewmr7_0624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI41627 ; ABI41627 ; Shewmr7_0624 .
    GeneIDi 4255821.
    KEGGi shm:Shewmr7_0624.
    PATRICi 23586141. VBISheSp85603_0648.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SSP60481:GHW6-652-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-7.

    Entry informationi

    Entry nameiGCSP_SHESR
    AccessioniPrimary (citable) accession number: Q0HZ28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3