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Q0HXU4

- SYL_SHESR

UniProt

Q0HXU4 - SYL_SHESR

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella sp. (strain MR-7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP60481:GHW6-1093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Shewmr7_1062
OrganismiShewanella sp. (strain MR-7)
Taxonomic identifieri60481 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001960: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_1000009428Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi60481.Shewmr7_1062.

Structurei

3D structure databases

ProteinModelPortaliQ0HXU4.
SMRiQ0HXU4. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0HXU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYNPSEI EALVQKHWHD NKTFEVTEDA NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARFQRLQG KNVLQPIGWD SFGLPAENAA INNKTAPAPW
110 120 130 140 150
TYQNIEYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTASVNWCP NDETVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE
210 220 230 240 250
ELLNDIDTLD GWPEQVKTMQ RNWIGRSEGV EMTFGVAGSD KSFDIYTTRP
260 270 280 290 300
DTLMGVTYVA IAAGHPLAEL AAQSNPELAQ FIEECKNSTT SEADLATMEK
310 320 330 340 350
RGVATGLYAI HPISGKQVPI WAANFVLMNY GTGAVMSVPG HDQRDYEFAK
360 370 380 390 400
KYNLPIEAVI KPVDGELDIS EAAYTEKGVL FNSGEFDGLD FDGAFNAIAD
410 420 430 440 450
KLVAEGKGKR QVNYRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPEDQLP
460 470 480 490 500
VILPEDVVMD GIQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPQADQM LDPTKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG
560 570 580 590 600
LVNSNEPAKQ LLTQGMVLAD AFYYTNDKGA RVWVSPLDVV TTEKDDKGRV
610 620 630 640 650
TKAIDKDGNE LVYTGMCKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP
660 670 680 690 700
PELTLEWQES GVEGAHRFIK RLWKLASDYV AQDNSEALDV SKLTSEQKAL
710 720 730 740 750
RREVHKTIAK VTDDIGRRQM FNTAVAAVME LMNHLQKAPQ TTGQDRAIIG
760 770 780 790 800
EALTAVVRLL YPIIPHVSFT LWNELGNTNS IEDSQWPVVD ESALVEDSKL
810 820 830 840 850
IVVQVNGKVR AKITVAADAD QASVEALGMA DEQVIKYLDG VTVRKVIYVP

GKLLSIVAN
Length:859
Mass (Da):96,762
Last modified:October 3, 2006 - v1
Checksum:i67902C106BAF69FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000444 Genomic DNA. Translation: ABI42061.1.
RefSeqiWP_011625476.1. NC_008322.1.
YP_737118.1. NC_008322.1.

Genome annotation databases

EnsemblBacteriaiABI42061; ABI42061; Shewmr7_1062.
GeneIDi4257322.
KEGGishm:Shewmr7_1062.
PATRICi23587047. VBISheSp85603_1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000444 Genomic DNA. Translation: ABI42061.1 .
RefSeqi WP_011625476.1. NC_008322.1.
YP_737118.1. NC_008322.1.

3D structure databases

ProteinModelPortali Q0HXU4.
SMRi Q0HXU4. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 60481.Shewmr7_1062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI42061 ; ABI42061 ; Shewmr7_1062 .
GeneIDi 4257322.
KEGGi shm:Shewmr7_1062.
PATRICi 23587047. VBISheSp85603_1099.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP60481:GHW6-1093-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-7.

Entry informationi

Entry nameiSYL_SHESR
AccessioniPrimary (citable) accession number: Q0HXU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3