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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Shewmr7_1681

Organism
Shewanella sp. (strain MR-7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSSP60481:GHW6-1765-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Shewmr7_1681Imported
OrganismiShewanella sp. (strain MR-7)Imported
Taxonomic identifieri60481 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001960 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ0HW30.
SMRiQ0HW30. Positions 5-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HW30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDNSPTIIY TETDEAPALA TLSLLPIIKT FTDAAGVAVE TRDISLSGRV
60 70 80 90 100
IANFPEKLTD AQKIGDHLAE LGELANQPEA NIIKLPNISA SIPQLKACIL
110 120 130 140 150
ELQQKGYDIP NYPDEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNFAKKN PHSMGKWSKE SQSHVAHMSE GDFYGSEQSV TLANADTVNI
210 220 230 240 250
VLSQKDGQEV VLKSGLKLLA GEIIDASVMS KKALVSFFER EIANAKAENV
260 270 280 290 300
LLSLHLKATM MKVSDPIMFG HAVKVFFKPV FDKHASLFAE LGVDVNNGFG
310 320 330 340 350
DVYAKIASLP ADVRAQIEAD IAAVYAERPA LAMVDSDKGI TNLHVPSDII
360 370 380 390 400
IDASMPAAIR SSGQMWGPDG KLHDTKALIP DRCYAGVYQE TIAFCKEHGA
410 420 430 440 450
FDPSTMGSVP NVGLMAQKAE EYGSHDKTFE IPADGVVNVI DASGKVLMSH
460 470 480 490 500
NVEAGDIWRM CQVKDAPIRD WVKLAVRRAR LSNTPAVFWL DANRAHDAQL
510 520 530 540 550
IAKVKQYLPE HDTSGLEISI MSPEEATRFS LVRIKEGKDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKEGH
610 620 630 640 650
LRWDSLGEFL ALAASLEHLS QTVGNPKAQV LADTLDQAIG QFLDSNKSPS
660 670 680 690 700
RRVGELDNRG SHFYLAMYWA QALAAQTKDE QLQAHFIPLA HALAANEQVI
710 720 730 740
VAELNNAQGA PVDLGGYYRL DAAKAEKAMR PSETLNKLLI A
Length:741
Mass (Da):80,486
Last modified:October 3, 2006 - v1
Checksum:iFB554DEA78B9D15C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000444 Genomic DNA. Translation: ABI42675.1.
RefSeqiWP_011625938.1. NC_008322.1.

Genome annotation databases

EnsemblBacteriaiABI42675; ABI42675; Shewmr7_1681.
KEGGishm:Shewmr7_1681.
PATRICi23588433. VBISheSp85603_1740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000444 Genomic DNA. Translation: ABI42675.1.
RefSeqiWP_011625938.1. NC_008322.1.

3D structure databases

ProteinModelPortaliQ0HW30.
SMRiQ0HW30. Positions 5-739.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI42675; ABI42675; Shewmr7_1681.
KEGGishm:Shewmr7_1681.
PATRICi23588433. VBISheSp85603_1740.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciSSP60481:GHW6-1765-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-7Imported.

Entry informationi

Entry nameiQ0HW30_SHESR
AccessioniPrimary (citable) accession number: Q0HW30
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 22, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.