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Q0HW30

- Q0HW30_SHESR

UniProt

Q0HW30 - Q0HW30_SHESR

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Shewmr7_1681

Organism
Shewanella sp. (strain MR-7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSSP60481:GHW6-1765-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Shewmr7_1681Imported
OrganismiShewanella sp. (strain MR-7)Imported
Taxonomic identifieri60481 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001960: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi60481.Shewmr7_1681.

Structurei

3D structure databases

ProteinModelPortaliQ0HW30.
SMRiQ0HW30. Positions 5-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HW30-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDNSPTIIY TETDEAPALA TLSLLPIIKT FTDAAGVAVE TRDISLSGRV
60 70 80 90 100
IANFPEKLTD AQKIGDHLAE LGELANQPEA NIIKLPNISA SIPQLKACIL
110 120 130 140 150
ELQQKGYDIP NYPDEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNFAKKN PHSMGKWSKE SQSHVAHMSE GDFYGSEQSV TLANADTVNI
210 220 230 240 250
VLSQKDGQEV VLKSGLKLLA GEIIDASVMS KKALVSFFER EIANAKAENV
260 270 280 290 300
LLSLHLKATM MKVSDPIMFG HAVKVFFKPV FDKHASLFAE LGVDVNNGFG
310 320 330 340 350
DVYAKIASLP ADVRAQIEAD IAAVYAERPA LAMVDSDKGI TNLHVPSDII
360 370 380 390 400
IDASMPAAIR SSGQMWGPDG KLHDTKALIP DRCYAGVYQE TIAFCKEHGA
410 420 430 440 450
FDPSTMGSVP NVGLMAQKAE EYGSHDKTFE IPADGVVNVI DASGKVLMSH
460 470 480 490 500
NVEAGDIWRM CQVKDAPIRD WVKLAVRRAR LSNTPAVFWL DANRAHDAQL
510 520 530 540 550
IAKVKQYLPE HDTSGLEISI MSPEEATRFS LVRIKEGKDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKEGH
610 620 630 640 650
LRWDSLGEFL ALAASLEHLS QTVGNPKAQV LADTLDQAIG QFLDSNKSPS
660 670 680 690 700
RRVGELDNRG SHFYLAMYWA QALAAQTKDE QLQAHFIPLA HALAANEQVI
710 720 730 740
VAELNNAQGA PVDLGGYYRL DAAKAEKAMR PSETLNKLLI A
Length:741
Mass (Da):80,486
Last modified:October 3, 2006 - v1
Checksum:iFB554DEA78B9D15C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000444 Genomic DNA. Translation: ABI42675.1.
RefSeqiWP_011625938.1. NC_008322.1.
YP_737732.1. NC_008322.1.

Genome annotation databases

EnsemblBacteriaiABI42675; ABI42675; Shewmr7_1681.
GeneIDi4256315.
KEGGishm:Shewmr7_1681.
PATRICi23588433. VBISheSp85603_1740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000444 Genomic DNA. Translation: ABI42675.1 .
RefSeqi WP_011625938.1. NC_008322.1.
YP_737732.1. NC_008322.1.

3D structure databases

ProteinModelPortali Q0HW30.
SMRi Q0HW30. Positions 5-739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 60481.Shewmr7_1681.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI42675 ; ABI42675 ; Shewmr7_1681 .
GeneIDi 4256315.
KEGGi shm:Shewmr7_1681.
PATRICi 23588433. VBISheSp85603_1740.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci SSP60481:GHW6-1765-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-7Imported.

Entry informationi

Entry nameiQ0HW30_SHESR
AccessioniPrimary (citable) accession number: Q0HW30
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3