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Q0HVQ8 (NAGZ_SHESR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:Shewmr7_1805
OrganismShewanella sp. (strain MR-7) [Complete proteome] [HAMAP]
Taxonomic identifier60481 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_1000005664

Regions

Region164 – 1652Substrate binding By similarity

Sites

Active site1771Proton donor/acceptor By similarity
Active site2491Nucleophile By similarity
Binding site611Substrate By similarity
Binding site691Substrate By similarity
Binding site1341Substrate By similarity
Site1751Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0HVQ8 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 684EFEFB64E87D92

FASTA34237,151
        10         20         30         40         50         60 
MSYLMLDLLS LDVSEAEAEM LRHPQVGGLI LFSRNFSSRE QLISLVQQIR QIRPEILIAV 

        70         80         90        100        110        120 
DHEGGRVQRF REGFTLIPAM GDILPAAKGD MLLAKRWACE LGFLMAIELL ACDIDLSFAP 

       130        140        150        160        170        180 
VLDLNGISQV IGKRSFSAKP DEVIALAQSF IEGMAEAGMG AVGKHFPGHG SVAADSHIAQ 

       190        200        210        220        230        240 
AIDEREAEAI FNQDILPFKE LIAKGKLSGI MPAHVIYPKV DPNPAGFSSY WLQQILRQEL 

       250        260        270        280        290        300 
GFDGVIFSDD LGMKGASFAG DYLGRAQAAL DAGCDMILVC NDNPGVMSLL NGFVWPDDAP 

       310        320        330        340 
QHPTSLLKPN VAQTAIALEN SARWENAKQL AEQIQLAQQA KV 

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. MR-7."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MR-7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000444 Genomic DNA. Translation: ABI42797.1.
RefSeqYP_737854.1. NC_008322.1.

3D structure databases

ProteinModelPortalQ0HVQ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING60481.Shewmr7_1805.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI42797; ABI42797; Shewmr7_1805.
GeneID4258390.
KEGGshm:Shewmr7_1805.
PATRIC23588675. VBISheSp85603_1860.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMALLNGFVW.
OrthoDBEOG6BCT06.

Enzyme and pathway databases

BioCycSSP60481:GHW6-1891-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGZ_SHESR
AccessionPrimary (citable) accession number: Q0HVQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries