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Q0HV08 (Q0HV08_SHESR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
Ordered Locus Names:Shewmr7_2059 EMBL ABI43047.1
OrganismShewanella sp. (strain MR-7) [Complete proteome] [HAMAP] EMBL ABI43047.1
Taxonomic identifier60481 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1481O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q0HV08 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: FFA016987C6FCEB8

FASTA944104,324
        10         20         30         40         50         60 
MPNHVFGPLN DTDYALSANF QGNEQFMTDL ASSISPINIE DELKNSYLDY AMSVIVGRAL 

        70         80         90        100        110        120 
PDVRDGLKPV HRRVLFAMSE LKNDWNKPYK KSARVVGDVI GKYHPHGDSA VYDTIVRMAQ 

       130        140        150        160        170        180 
PFSLRYTLVD GQGNFGSVDG DSAAAMRYTE IRMDKLAHQL LADLEKETVD YVPNYDGTEQ 

       190        200        210        220        230        240 
IPAVLPTRVP NLLINGSSGI AVGMATNIPP HNLTEVVKGC LALIADPALS IEQLMEHIPG 

       250        260        270        280        290        300 
PDFPTAAIIN GRKGIIDAYK TGRGRAVMRA LAEVETEDNG RERIIVTEIP YQVNKAKLIE 

       310        320        330        340        350        360 
KIAELVKDKK IEGISGLRDE SDKDGMRIVI EIKRGEVGEV VLNNLYAQTQ MQCSFGINMV 

       370        380        390        400        410        420 
ALTNGQPKLF NLKEMLECFI LHRREVVTRR TVFELRKARE RAHILEALAV ALANIDPIIA 

       430        440        450        460        470        480 
LIKASPTPAD AKVKLVEQGW ALGHVQGMLE KAGDDAARPE WLEPEFGIRD GLYYLTEQQA 

       490        500        510        520        530        540 
QAILELRLHR LTGLEHDKII AEYEELLEFI AGLLFILRSP ERLMEVIKEE LEEILAEYGD 

       550        560        570        580        590        600 
ARRTVINANE IDMSLEDLIN EEDVVVTLSH LGYAKYQPLS DYQAQRRGGK GKAATKVKDE 

       610        620        630        640        650        660 
DFVEKLLVAN THDTILCFSD FGKMYWLKVY QLPLASRTSR GRPIVNLLPL SDGERITAIL 

       670        680        690        700        710        720 
PVREYAEDKY IIMATSNGTV KKTALTAYSN PRANGIIAVN LKDGDQLIGV DITNGDDEIM 

       730        740        750        760        770        780 
LFSNEGKVVR FKEGEEVAVL DENGNPVLDE EGNPQINFKG VRPMGRGATG VRGIKLEEGQ 

       790        800        810        820        830        840 
KVVSLIVPKG DGAILTVTEN GYGKRTELSE YPSKSRATKG VVSIKVSERN GAVVGAVQVG 

       850        860        870        880        890        900 
GNDEIMLISD KGTLVRTPAN GVSIIGRNTQ GVTIIRTASD EKVVGLQRID EIQGDEDEVE 

       910        920        930        940 
LDENGMPIVP VVAEGDSVHE EPLEEELEEE LDEDEELDDE QDED

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References

[1]"Complete sequence of chromosome 1 of Shewanella sp. MR-7."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MR-7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000444 Genomic DNA. Translation: ABI43047.1.
RefSeqYP_738104.1. NC_008322.1.

3D structure databases

ProteinModelPortalQ0HV08.
SMRQ0HV08. Positions 56-546, 561-891.
ModBaseSearch...

Protein-protein interaction databases

STRING60481.Shewmr7_2059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI43047; ABI43047; Shewmr7_2059.
GeneID4255930.
KEGGshm:Shewmr7_2059.
PATRIC23589229. VBISheSp85603_2123.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0HV08_SHESR
AccessionPrimary (citable) accession number: Q0HV08
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info