Reviewed, UniProtKB/Swiss-Prot Q0HTT9 (CDD_SHESR)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	Shewmr7_2481

Organism

Shewanella sp. (strain MR-7) [Complete proteome] [HAMAP]

Taxonomic identifier

60481 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Cytidine deaminase HAMAP MF_01558		PRO_1000068967
Regions
	Region	88 – 90	3	Substrate binding By similarity
Sites
	Active site	103	1	Proton donor By similarity
	Metal binding	101	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
	Metal binding	131	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0HTT9-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 537E2442A26A4CF2	FASTA	296	32,082
	10 20 30 40 50 60 MQDRFIRSIT QLPTPLADAL IPLLHQNFAG HIDAQQLAEL VQSSQMTEAE VLLALLPIAA 70 80 90 100 110 120 ALAKPPISEF YVGAIAKGKS GDIYMGANLE LPGEALFHSV HAEQSAISHA WLSGESQIVD 130 140 150 160 170 180 MIVNASPCGH CRQFMNELVE GGQIKIHLPS QDSHLLSYYL PYAFGPKDLN VQSPLLVKHE 190 200 210 220 230 240 TEFALDSSDP MVIEALDHAG LSYAPYTQSY AAVVLETADG ATYCGRYAEN AAFNPSMLPM 250 260 270 280 290 QMALSNLTRH NRDFGEIRRA VLVESSQGKI SLVGATMDAL HPVAAIELEH IVVDPV

References

[1]

"Complete sequence of chromosome 1 of Shewanella sp. MR-7." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000444 Genomic DNA. Translation: ABI43466.1.
RefSeq	YP_738523.1.
3D structure databases
SMR	Q0HTT9. Positions 1-293.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0HTT9.
Genome annotation databases
GeneID	4256370.
GenomeReviews	Gene locus Shewmr7_2481 in contig CP000444_GR.
KEGG	shm:Shewmr7_2481.
NMPDR	fig|60481.10.peg.2346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0295.
HOGENOM	HBG591160.
OMA	NRSHAPY.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_SHESR

Accession

Primary (citable) accession number: Q0HTT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 3, 2006
Last modified:	January 19, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)