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Reviewed, UniProtKB/Swiss-Prot Q0HRB0 (NRFA_SHESR)

Last modified November 4, 2008. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome c-552
    EC=1.7.2.2
Alternative name(s):
    Ammonia-forming cytochrome c nitrite reductase
      Short name=Cytochrome c nitrite reductase
Gene names
Name: nrfA
Ordered Locus Names: Shewmr7_3363
OrganismShewanella sp. (strain MR-7) [Complete proteome] [HAMAP]
Taxonomic identifier60481 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

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Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Plays a role in nitrite reduction By similarity.

Catalytic activity

NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+).

Cofactor

Binds 1 calcium ion per monomer By similarity.

Binds 5 heme groups covalently per monomer By similarity.

Pathway

Nitrogen metabolism; nitrate reduction (assimilation).

Subcellular location

PeriplasmBy similarity.

Sequence similarities

Belongs to the cytochrome c-552 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 467440Cytochrome c-552
PRO_0000268977

Sites

Metal binding871Iron (heme 3 axial ligand) By similarity
Metal binding1191Iron (heme 1 axial ligand) By similarity
Metal binding1571Iron (heme 2 axial ligand) By similarity
Metal binding1991Iron (heme 3 axial ligand) By similarity
Metal binding2011Calcium By similarity
Metal binding2021Calcium; via carbonyl oxygen By similarity
Metal binding2501Calcium; via carbonyl oxygen By similarity
Metal binding2521Calcium By similarity
Metal binding2641Iron (heme 5 axial ligand) By similarity
Metal binding2751Iron (heme 4 axial ligand) By similarity
Metal binding2901Iron (heme 2 axial ligand) By similarity
Metal binding3071Iron (heme 5 axial ligand) By similarity
Metal binding3821Iron (heme 4 axial ligand) By similarity
Binding site1151Heme 1 (covalent) By similarity
Binding site1181Heme 1 (covalent) By similarity
Binding site1531Heme 2 (covalent) By similarity
Binding site1561Heme 2 (covalent) By similarity
Binding site1951Heme 3 (covalent) By similarity
Binding site1981Heme 3 (covalent) By similarity
Binding site2021Substrate By similarity
Binding site2531Substrate By similarity
Binding site2711Heme 4 (covalent) By similarity
Binding site2741Heme 4 (covalent) By similarity
Binding site3031Heme 5 (covalent) By similarity
Binding site3061Heme 5 (covalent) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q0HRB0-1 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: 2CCCF72DE6260D00

FASTA46751,955
        10         20         30         40         50         60 
MMKKMTGKSF ALSALVAASF MAAGAMASDK TEPRNEVYKD KFANQYNSWH DTAKSEEITD 

        70         80         90        100        110        120 
ALAGDPSLVI LWAGYGFAKD YNAPRGHMYA VTDVRNTLRT GAPTNAEDGP MPMACWSCKS 

       130        140        150        160        170        180 
PDVPRLIEEQ GEDGYFKGKW AKGGPEVVNT IGCSDCHEKG TPKLRISRPF AERGMEALGT 

       190        200        210        220        230        240 
PFDKASKKDK QSMVCGQCHV EYYFEKKDDR KGFVKFPWDS GTTVEQMEAY YDAIEFSDWT 

       250        260        270        280        290        300 
HSLSKTPMLK AQHPGYETWK MGVHGKNDVS CVDCHMPKVT NDKGRKYTDH KVGNPFDRFD 

       310        320        330        340        350        360 
ETCATCHSQS KEFLEGITKE RYAKVKELKA RAEGQLVKAH FEAAKAWEVG ATEAEMKPIL 

       370        380        390        400        410        420 
TDIRHAQWRW DFAIASHGVA AHAPEEALRI LGTAVDKAAD ARVKLAQLLA KKGVTDAVAI 

       430        440        450        460 
PDISTKAKAQ AALGMDMDKM NAEKEAFKKD MLPKWDAEAK KREATYK

« Hide

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References

[1]"Complete sequence of chromosome 1 of Shewanella sp. MR-7."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000444 Genomic DNA. Translation: ABI44345.1. Different initiation.
RefSeqYP_739402.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4255318.
GenomeReviewsGene locus Shewmr7_3363 in contig CP000444_GR.
KEGGshm:Shewmr7_3363.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ0HRB0.

Family and domain databases

HAMAPMF_01182.
[Tree]
InterProIPR003321. Cyt_c552.
IPR017570. Cytc_552_NO2Rdtase_formate-dep.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamPF02335. Cytochrom_C552. 1 hit.
[Graphical view]
PIRSFPIRSF000243. Cyt_c552. 1 hit.
PROSITEPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNRFA_SHESR
AccessionPrimary (citable) accession number: Q0HRB0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: November 4, 2008
This is version 21 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents