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Protein

Thiopurine S-methyltransferase

Gene

tpm

Organism
Shewanella sp. (strain MR-7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10S-adenosyl-L-methionineUniRule annotation1
Binding sitei45S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei66S-adenosyl-L-methionineUniRule annotation1
Binding sitei123S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)
Alternative name(s):
Thiopurine methyltransferaseUniRule annotation
Gene namesi
Name:tpmUniRule annotation
Ordered Locus Names:Shewmr7_3449
OrganismiShewanella sp. (strain MR-7)
Taxonomic identifieri60481 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001960 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000472251 – 218Thiopurine S-methyltransferaseAdd BLAST218

Structurei

3D structure databases

ProteinModelPortaliQ0HR25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276919
KOiK00569
OMAiMKWFADR

Family and domain databases

HAMAPiMF_00812 Thiopur_methtran, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR022474 Thiopur_S-MeTfrase_Se/Te_detox
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT
PANTHERiPTHR10259 PTHR10259, 1 hit
PTHR10259:SF16 PTHR10259:SF16, 1 hit
PfamiView protein in Pfam
PF05724 TPMT, 1 hit
PIRSFiPIRSF023956 Thiopurine_S-methyltransferase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR03840 TMPT_Se_Te, 1 hit
PROSITEiView protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q0HR25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGFWHEKW QQQLIGFHQQ DINPFLVKYW QTLALPADAK VFVPLCGKSL
60 70 80 90 100
DMCFLAEQGH QVIGCELNEL AVQQFFEENQ LPMKKSAEGE HQHYHTEQVS
110 120 130 140 150
LYQGDIFTLP QSITAKVSGF YDRAALIAWP ESMRTQYAKQ LAQLLPSGSV
160 170 180 190 200
GLLVTLDYPQ EALSGPPFAV SPTWVETHLS DDFEIQALAC QDVLADNPRF
210
VKKEVPWLNE AVYLLRRK
Length:218
Mass (Da):24,864
Last modified:October 3, 2006 - v1
Checksum:iA0CDA6E8A5EDE114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000444 Genomic DNA Translation: ABI44430.1
RefSeqiWP_011627265.1, NC_008322.1

Genome annotation databases

EnsemblBacteriaiABI44430; ABI44430; Shewmr7_3449
KEGGishm:Shewmr7_3449

Similar proteinsi

Entry informationi

Entry nameiTPMT_SHESR
AccessioniPrimary (citable) accession number: Q0HR25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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