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Q0HR05

- FTHS_SHESR

UniProt

Q0HR05 - FTHS_SHESR

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sp. (strain MR-7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP60481:GHW6-3601-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Shewmr7_3469
    OrganismiShewanella sp. (strain MR-7)
    Taxonomic identifieri60481 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001960: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Formate--tetrahydrofolate ligasePRO_0000300540Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi60481.Shewmr7_3469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0HR05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0HR05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTDMDISRR ADLKDIAALG AEFGLLPDEM QLFGKTKAKV DLRVQQRLAE    50
    QQGKLIIVTA VTPTPHGEGK TVTTIGLTQS LKALGNKVCA CIRQPSMGPV 100
    FGVKGGAAGG GYAQVVPMQE LNLHLTGDIH AVSSAHNLGA AAIASRLYHE 150
    TRLGKAEFEL QSGQNYLDIA PNGIRWHRVV DHNDRCLREI EVGLGENNGP 200
    AYTSGFDITA ASELMAILAL SRNLADMRAR IGKLVLAVNR QGAAISAEDL 250
    GVAGAMTALM ADAVKPTLMQ TLNGAPCLIH AGPFANIAHG NSSVIADDIA 300
    LKLADFVVTE GGFGSDMGFE KFCNIKARQS GLAPSTAVLV TTLKALKANS 350
    GLTSDADINA PDQARLEAGF ANLNWHINNV ARYGIPVVVA INRFATDTDA 400
    ELNWLIEAVS GTAAFGCELS ETFSQGEAGA LALAQTVMRA CEQPSEFTLL 450
    YPDDMALEAK LSTLAEVGYG AAGVSLSEAA KLQLQELSAL GYAHLPVCMA 500
    KTPLSISHDP QLKGVPQGFI VPVRELVLNA GAGFITALVG NVMTMPGLGL 550
    VPGYLKIDIG ADGEITGLG 569
    Length:569
    Mass (Da):59,585
    Last modified:October 3, 2006 - v1
    Checksum:iFD9E42B843914AB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000444 Genomic DNA. Translation: ABI44450.1.
    RefSeqiWP_011627283.1. NC_008322.1.
    YP_739507.1. NC_008322.1.

    Genome annotation databases

    EnsemblBacteriaiABI44450; ABI44450; Shewmr7_3469.
    GeneIDi4257665.
    KEGGishm:Shewmr7_3469.
    PATRICi23592183. VBISheSp85603_3576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000444 Genomic DNA. Translation: ABI44450.1 .
    RefSeqi WP_011627283.1. NC_008322.1.
    YP_739507.1. NC_008322.1.

    3D structure databases

    ProteinModelPortali Q0HR05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 60481.Shewmr7_3469.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI44450 ; ABI44450 ; Shewmr7_3469 .
    GeneIDi 4257665.
    KEGGi shm:Shewmr7_3469.
    PATRICi 23592183. VBISheSp85603_3576.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSP60481:GHW6-3601-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-7.

    Entry informationi

    Entry nameiFTHS_SHESR
    AccessioniPrimary (citable) accession number: Q0HR05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3