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Q0HR05

- FTHS_SHESR

UniProt

Q0HR05 - FTHS_SHESR

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Shewmr7_3469
Organism
Shewanella sp. (strain MR-7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP60481:GHW6-3601-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Shewmr7_3469
OrganismiShewanella sp. (strain MR-7)
Taxonomic identifieri60481 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001960: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000300540Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi60481.Shewmr7_3469.

Structurei

3D structure databases

ProteinModelPortaliQ0HR05.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0HR05-1 [UniParc]FASTAAdd to Basket

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MLTDMDISRR ADLKDIAALG AEFGLLPDEM QLFGKTKAKV DLRVQQRLAE    50
QQGKLIIVTA VTPTPHGEGK TVTTIGLTQS LKALGNKVCA CIRQPSMGPV 100
FGVKGGAAGG GYAQVVPMQE LNLHLTGDIH AVSSAHNLGA AAIASRLYHE 150
TRLGKAEFEL QSGQNYLDIA PNGIRWHRVV DHNDRCLREI EVGLGENNGP 200
AYTSGFDITA ASELMAILAL SRNLADMRAR IGKLVLAVNR QGAAISAEDL 250
GVAGAMTALM ADAVKPTLMQ TLNGAPCLIH AGPFANIAHG NSSVIADDIA 300
LKLADFVVTE GGFGSDMGFE KFCNIKARQS GLAPSTAVLV TTLKALKANS 350
GLTSDADINA PDQARLEAGF ANLNWHINNV ARYGIPVVVA INRFATDTDA 400
ELNWLIEAVS GTAAFGCELS ETFSQGEAGA LALAQTVMRA CEQPSEFTLL 450
YPDDMALEAK LSTLAEVGYG AAGVSLSEAA KLQLQELSAL GYAHLPVCMA 500
KTPLSISHDP QLKGVPQGFI VPVRELVLNA GAGFITALVG NVMTMPGLGL 550
VPGYLKIDIG ADGEITGLG 569
Length:569
Mass (Da):59,585
Last modified:October 3, 2006 - v1
Checksum:iFD9E42B843914AB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000444 Genomic DNA. Translation: ABI44450.1.
RefSeqiWP_011627283.1. NC_008322.1.
YP_739507.1. NC_008322.1.

Genome annotation databases

EnsemblBacteriaiABI44450; ABI44450; Shewmr7_3469.
GeneIDi4257665.
KEGGishm:Shewmr7_3469.
PATRICi23592183. VBISheSp85603_3576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000444 Genomic DNA. Translation: ABI44450.1 .
RefSeqi WP_011627283.1. NC_008322.1.
YP_739507.1. NC_008322.1.

3D structure databases

ProteinModelPortali Q0HR05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 60481.Shewmr7_3469.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI44450 ; ABI44450 ; Shewmr7_3469 .
GeneIDi 4257665.
KEGGi shm:Shewmr7_3469.
PATRICi 23592183. VBISheSp85603_3576.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSP60481:GHW6-3601-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-7.

Entry informationi

Entry nameiFTHS_SHESR
AccessioniPrimary (citable) accession number: Q0HR05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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