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Q0HR05 (FTHS_SHESR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Shewmr7_3469
OrganismShewanella sp. (strain MR-7) [Complete proteome] [HAMAP]
Taxonomic identifier60481 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300540

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0HR05 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: FD9E42B843914AB0

FASTA56959,585
        10         20         30         40         50         60 
MLTDMDISRR ADLKDIAALG AEFGLLPDEM QLFGKTKAKV DLRVQQRLAE QQGKLIIVTA 

        70         80         90        100        110        120 
VTPTPHGEGK TVTTIGLTQS LKALGNKVCA CIRQPSMGPV FGVKGGAAGG GYAQVVPMQE 

       130        140        150        160        170        180 
LNLHLTGDIH AVSSAHNLGA AAIASRLYHE TRLGKAEFEL QSGQNYLDIA PNGIRWHRVV 

       190        200        210        220        230        240 
DHNDRCLREI EVGLGENNGP AYTSGFDITA ASELMAILAL SRNLADMRAR IGKLVLAVNR 

       250        260        270        280        290        300 
QGAAISAEDL GVAGAMTALM ADAVKPTLMQ TLNGAPCLIH AGPFANIAHG NSSVIADDIA 

       310        320        330        340        350        360 
LKLADFVVTE GGFGSDMGFE KFCNIKARQS GLAPSTAVLV TTLKALKANS GLTSDADINA 

       370        380        390        400        410        420 
PDQARLEAGF ANLNWHINNV ARYGIPVVVA INRFATDTDA ELNWLIEAVS GTAAFGCELS 

       430        440        450        460        470        480 
ETFSQGEAGA LALAQTVMRA CEQPSEFTLL YPDDMALEAK LSTLAEVGYG AAGVSLSEAA 

       490        500        510        520        530        540 
KLQLQELSAL GYAHLPVCMA KTPLSISHDP QLKGVPQGFI VPVRELVLNA GAGFITALVG 

       550        560 
NVMTMPGLGL VPGYLKIDIG ADGEITGLG 

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. MR-7."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MR-7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000444 Genomic DNA. Translation: ABI44450.1.
RefSeqYP_739507.1. NC_008322.1.

3D structure databases

ProteinModelPortalQ0HR05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING60481.Shewmr7_3469.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI44450; ABI44450; Shewmr7_3469.
GeneID4257665.
KEGGshm:Shewmr7_3469.
PATRIC23592183. VBISheSp85603_3576.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycSSP60481:GHW6-3601-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SHESR
AccessionPrimary (citable) accession number: Q0HR05
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways