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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi266Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSP60480:G1G76-330-MONOMER

Protein family/group databases

PeroxiBasei3649 SHspCP02_MR-4

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:Shewmr4_0311
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_000035492523 – 728Catalase-peroxidase 1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ0HNH6

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0HNH6
SMRiQ0HNH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0HNH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTQSSQGK CPVMHGANSA VASNNMDWWP KALNLDILHQ HDKKTDPMDP
60 70 80 90 100
KFNYREAFNS LDLAAVKRDL NALMTDSQDW WPADWGHYGG LMIRMAWHSA
110 120 130 140 150
GTYRVADGRG GAGTGNQRFA PLNSWPDNAN LDKARRLLWP IKKKYGNKLS
160 170 180 190 200
WADLMILAGN VAYESMGLKT YGFAGGREDI WHPEKDIYWG SEKQWLAPTE
210 220 230 240 250
NPNSRYSGER DLENPLAAVM MGLIYVNPEG VDGKPDPLRT AQDVRVTFAR
260 270 280 290 300
MAMNDEETVA LTAGGHTVGK CHGNGKAQDL GPEPEGEDLE AQGLGWLNKK
310 320 330 340 350
GPGIGANAVT SGLEGAWTTY PTQWDNGYFH LLLNYDWELK KSPAGASQWE
360 370 380 390 400
PINIKEEDKV VSVGDPNRKF NPIMTDADMA MKMDPEYRKI SEKFYQDPAY
410 420 430 440 450
FSEVFARAWF KLTHRDLGPK SRYLGPEVPN EDLLWQDPIP SVDYRLDASE
460 470 480 490 500
IVDLKAKLLA SGLSVSELVA TAWDSARTFR GSDFRGGANG ARIRLAPQKD
510 520 530 540 550
WQANEPERLQ KVLKVLTELQ ASLSKKVSIA DLIVLGGAAA IEKAAHEAGV
560 570 580 590 600
KVTVPFIPGR GDATQEMTDV ESFAVLEPLH DAYRNWQKKD YVVQPEEMML
610 620 630 640 650
DRTQLMGLTA HEMTVLVGGM RVLGTNYGGT RHGVFTDKVG VLTNDFFVNL
660 670 680 690 700
TDMAYNWKPA GSNLYQIVER KTGAVKWTAS RVDLVFGSNS ILRAYAEMYA
710 720
QDDAKEKFVH DFVAAWTKVM NADRFDLA
Length:728
Mass (Da):81,170
Last modified:October 3, 2006 - v1
Checksum:i6F1F22CCF3B9D472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA Translation: ABI37391.1
RefSeqiWP_011621117.1, NC_008321.1

Genome annotation databases

EnsemblBacteriaiABI37391; ABI37391; Shewmr4_0311
KEGGishe:Shewmr4_0311

Similar proteinsi

Entry informationi

Entry nameiKATG1_SHESM
AccessioniPrimary (citable) accession number: Q0HNH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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