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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi266 – 2661Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSP60480:GI2N-330-MONOMER.

Protein family/group databases

PeroxiBasei3649. SHspCP02_MR-4.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:Shewmr4_0311
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222UniRule annotationAdd
BLAST
Chaini23 – 728706Catalase-peroxidase 1PRO_0000354925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0HNH6.
SMRiQ0HNH6. Positions 27-727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0HNH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTQSSQGK CPVMHGANSA VASNNMDWWP KALNLDILHQ HDKKTDPMDP
60 70 80 90 100
KFNYREAFNS LDLAAVKRDL NALMTDSQDW WPADWGHYGG LMIRMAWHSA
110 120 130 140 150
GTYRVADGRG GAGTGNQRFA PLNSWPDNAN LDKARRLLWP IKKKYGNKLS
160 170 180 190 200
WADLMILAGN VAYESMGLKT YGFAGGREDI WHPEKDIYWG SEKQWLAPTE
210 220 230 240 250
NPNSRYSGER DLENPLAAVM MGLIYVNPEG VDGKPDPLRT AQDVRVTFAR
260 270 280 290 300
MAMNDEETVA LTAGGHTVGK CHGNGKAQDL GPEPEGEDLE AQGLGWLNKK
310 320 330 340 350
GPGIGANAVT SGLEGAWTTY PTQWDNGYFH LLLNYDWELK KSPAGASQWE
360 370 380 390 400
PINIKEEDKV VSVGDPNRKF NPIMTDADMA MKMDPEYRKI SEKFYQDPAY
410 420 430 440 450
FSEVFARAWF KLTHRDLGPK SRYLGPEVPN EDLLWQDPIP SVDYRLDASE
460 470 480 490 500
IVDLKAKLLA SGLSVSELVA TAWDSARTFR GSDFRGGANG ARIRLAPQKD
510 520 530 540 550
WQANEPERLQ KVLKVLTELQ ASLSKKVSIA DLIVLGGAAA IEKAAHEAGV
560 570 580 590 600
KVTVPFIPGR GDATQEMTDV ESFAVLEPLH DAYRNWQKKD YVVQPEEMML
610 620 630 640 650
DRTQLMGLTA HEMTVLVGGM RVLGTNYGGT RHGVFTDKVG VLTNDFFVNL
660 670 680 690 700
TDMAYNWKPA GSNLYQIVER KTGAVKWTAS RVDLVFGSNS ILRAYAEMYA
710 720
QDDAKEKFVH DFVAAWTKVM NADRFDLA
Length:728
Mass (Da):81,170
Last modified:October 3, 2006 - v1
Checksum:i6F1F22CCF3B9D472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI37391.1.
RefSeqiWP_011621117.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI37391; ABI37391; Shewmr4_0311.
KEGGishe:Shewmr4_0311.
PATRICi23577040. VBISheSp133532_0325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI37391.1.
RefSeqiWP_011621117.1. NC_008321.1.

3D structure databases

ProteinModelPortaliQ0HNH6.
SMRiQ0HNH6. Positions 27-727.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3649. SHspCP02_MR-4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI37391; ABI37391; Shewmr4_0311.
KEGGishe:Shewmr4_0311.
PATRICi23577040. VBISheSp133532_0325.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.

Enzyme and pathway databases

BioCyciSSP60480:GI2N-330-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG1_SHESM
AccessioniPrimary (citable) accession number: Q0HNH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.