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Q0HMS6

- FTHS_SHESM

UniProt

Q0HMS6 - FTHS_SHESM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP60480:GI2N-584-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Shewmr4_0561
    OrganismiShewanella sp. (strain MR-4)
    Taxonomic identifieri60480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008079: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_0000300539Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi60480.Shewmr4_0561.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0HMS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0HMS6-1 [UniParc]FASTAAdd to Basket

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    MLTDMDISRR APLKDIAVLG AEFGLLPDEM QLFGKTKAKV DLRVQQRLAE    50
    QQQGKLIIVT AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP 100
    VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSNAHNLG AAAIASRLYH 150
    ETRLGKAEFE LQSGQNYLDI APNGIRWHRV VDHNDRCLRE IEVGLGENNG 200
    PAYTSGFDIT AASELMAILA LSRNLADMRA RIGKLVLAVN RQGAAISAED 250
    LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI 300
    ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLTPSAAVL VTTLKALKAN 350
    SGLTSDADIN APDQARLEAG FANLNWHINN VARYGIPVVV AINRFATDTD 400
    AELNWLIEAV AGTAAFGCEL SEAFSQGEAG ALALAQTVMR ACEQPSEFTL 450
    LYPDDMALEA KLSTLAEVGY GAAGVSLSEA AKLQLQELSA LGYADLPVCM 500
    AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV GNVMTMPGLG 550
    LVPGYLKIDI GADGEITGLG 570
    Length:570
    Mass (Da):59,683
    Last modified:October 3, 2006 - v1
    Checksum:iE71CD9252ABE60E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI37641.1.
    RefSeqiWP_011621363.1. NC_008321.1.
    YP_732698.1. NC_008321.1.

    Genome annotation databases

    EnsemblBacteriaiABI37641; ABI37641; Shewmr4_0561.
    GeneIDi4251789.
    KEGGishe:Shewmr4_0561.
    PATRICi23577558. VBISheSp133532_0580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI37641.1 .
    RefSeqi WP_011621363.1. NC_008321.1.
    YP_732698.1. NC_008321.1.

    3D structure databases

    ProteinModelPortali Q0HMS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 60480.Shewmr4_0561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI37641 ; ABI37641 ; Shewmr4_0561 .
    GeneIDi 4251789.
    KEGGi she:Shewmr4_0561.
    PATRICi 23577558. VBISheSp133532_0580.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSP60480:GI2N-584-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-4.

    Entry informationi

    Entry nameiFTHS_SHESM
    AccessioniPrimary (citable) accession number: Q0HMS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3