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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei317Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciSSP60480:G1G76-876-MONOMER
UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Shewmr4_0842
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000216311 – 350Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST350

Proteomic databases

PRIDEiQ0HLZ5

Structurei

3D structure databases

ProteinModelPortaliQ0HLZ5
SMRiQ0HLZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263500
KOiK00768
OMAiQMATFAE

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q0HLZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSTLLFQI EPASRAQDQF IQQKIDLKTK PPGALGLLEP LALQIARIQG
60 70 80 90 100
PKQLEIVNPT MLVFAGDHGI AAEGVSIAPS EVTRQMVQNF AHGGAAINVF
110 120 130 140 150
CRQLGFNLEV IDCGILTPVE GVEGIIDQRL GAGTGAIHLE PAMSLACVDK
160 170 180 190 200
GFAMAQALIE RHHQAGCNLV AFGEMGIGNT SSAAAIMAAI MQLDVADCVG
210 220 230 240 250
RGTGISSETL ERKQMLIELA LLLHQSAMTG PKQVLACLGG FEIVQMTGAM
260 270 280 290 300
LAAAERKMLV VVDGFIATAA ALVAVTINAH VRDYLIFAHR SEEQGHQRML
310 320 330 340 350
EHLKAKPLLS LGLRLGEGTG AALALPLIQA AVNFYNQMAS FSDAGIEAVV
Length:350
Mass (Da):36,949
Last modified:October 3, 2006 - v1
Checksum:iFB6C7D139664B268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA Translation: ABI37922.1
RefSeqiWP_011621637.1, NC_008321.1

Genome annotation databases

EnsemblBacteriaiABI37922; ABI37922; Shewmr4_0842
KEGGishe:Shewmr4_0842

Entry informationi

Entry nameiCOBT_SHESM
AccessioniPrimary (citable) accession number: Q0HLZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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