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Q0HLM3

- DAPB_SHESM

UniProt

Q0HLM3 - DAPB_SHESM

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotation

    Catalytic activityi

    (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371NADUniRule annotation
    Binding sitei38 – 381NADPUniRule annotation
    Active sitei158 – 1581Proton donor/acceptorUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation
    Active sitei162 – 1621Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NAD(P)UniRule annotation
    Nucleotide bindingi101 – 1033NAD(P)UniRule annotation
    Nucleotide bindingi125 – 1284NAD(P)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADPH binding Source: InterPro
    4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciSSP60480:GI2N-994-MONOMER.
    UniPathwayiUPA00034; UER00018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
    Short name:
    HTPA reductaseUniRule annotation
    Gene namesi
    Name:dapBUniRule annotation
    Ordered Locus Names:Shewmr4_0964
    OrganismiShewanella sp. (strain MR-4)
    Taxonomic identifieri60480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008079: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2702704-hydroxy-tetrahydrodipicolinate reductasePRO_1000008639Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi60480.Shewmr4_0964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0HLM3.
    SMRiQ0HLM3. Positions 5-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni168 – 1692Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DapB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0289.
    HOGENOMiHOG000227153.
    KOiK00215.
    OMAiHTVWFAD.
    OrthoDBiEOG6SV5DS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00102. DapB.
    InterProiIPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR20836. PTHR20836. 1 hit.
    PfamiPF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000161. DHPR. 1 hit.
    TIGRFAMsiTIGR00036. dapB. 1 hit.
    PROSITEiPS01298. DAPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0HLM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGQVRVAIV GAGGRMGRTL IESAYHQEHI RLGAAIERPG SSLVGVDAGE    50
    LAGVGKLNVL VMDSLDYATD DFDVLIDFTA PEASIVHLDW CVRHKKAMVI 100
    GTTGFNHAQK EQINAFAEQT PVVMAPNMSV GVNLMWKLLE LAAEVMGDYT 150
    DIEIIEGHHR HKKDAPSGTA LKMGEVIAKT LGRDLEKCAV YGREGITGER 200
    DRETIGFATV RAGDLVGEHT AMFADIGERL EITHKASSRM TFANGAMRAA 250
    HWLVEQKPGL YDMQQVLGLN 270
    Length:270
    Mass (Da):29,279
    Last modified:October 3, 2006 - v1
    Checksum:i92CC873EB4AD46F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI38044.1.
    RefSeqiYP_733101.1. NC_008321.1.

    Genome annotation databases

    EnsemblBacteriaiABI38044; ABI38044; Shewmr4_0964.
    GeneIDi4251615.
    KEGGishe:Shewmr4_0964.
    PATRICi23578406. VBISheSp133532_1000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI38044.1 .
    RefSeqi YP_733101.1. NC_008321.1.

    3D structure databases

    ProteinModelPortali Q0HLM3.
    SMRi Q0HLM3. Positions 5-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 60480.Shewmr4_0964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI38044 ; ABI38044 ; Shewmr4_0964 .
    GeneIDi 4251615.
    KEGGi she:Shewmr4_0964.
    PATRICi 23578406. VBISheSp133532_1000.

    Phylogenomic databases

    eggNOGi COG0289.
    HOGENOMi HOG000227153.
    KOi K00215.
    OMAi HTVWFAD.
    OrthoDBi EOG6SV5DS.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00018 .
    BioCyci SSP60480:GI2N-994-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00102. DapB.
    InterProi IPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR20836. PTHR20836. 1 hit.
    Pfami PF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000161. DHPR. 1 hit.
    TIGRFAMsi TIGR00036. dapB. 1 hit.
    PROSITEi PS01298. DAPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-4.

    Entry informationi

    Entry nameiDAPB_SHESM
    AccessioniPrimary (citable) accession number: Q0HLM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.Curated

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3