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Q0HLM3

- DAPB_SHESM

UniProt

Q0HLM3 - DAPB_SHESM

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Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotation

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371NADUniRule annotation
Binding sitei38 – 381NADPUniRule annotation
Active sitei158 – 1581Proton donor/acceptorUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Active sitei162 – 1621Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD(P)UniRule annotation
Nucleotide bindingi101 – 1033NAD(P)UniRule annotation
Nucleotide bindingi125 – 1284NAD(P)UniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciSSP60480:GI2N-994-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
Short name:
HTPA reductaseUniRule annotation
Gene namesi
Name:dapBUniRule annotation
Ordered Locus Names:Shewmr4_0964
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008079: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2702704-hydroxy-tetrahydrodipicolinate reductasePRO_1000008639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi60480.Shewmr4_0964.

Structurei

3D structure databases

ProteinModelPortaliQ0HLM3.
SMRiQ0HLM3. Positions 5-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 1692Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DapB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0289.
HOGENOMiHOG000227153.
KOiK00215.
OMAiHTVWFAD.
OrthoDBiEOG6SV5DS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0HLM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGQVRVAIV GAGGRMGRTL IESAYHQEHI RLGAAIERPG SSLVGVDAGE
60 70 80 90 100
LAGVGKLNVL VMDSLDYATD DFDVLIDFTA PEASIVHLDW CVRHKKAMVI
110 120 130 140 150
GTTGFNHAQK EQINAFAEQT PVVMAPNMSV GVNLMWKLLE LAAEVMGDYT
160 170 180 190 200
DIEIIEGHHR HKKDAPSGTA LKMGEVIAKT LGRDLEKCAV YGREGITGER
210 220 230 240 250
DRETIGFATV RAGDLVGEHT AMFADIGERL EITHKASSRM TFANGAMRAA
260 270
HWLVEQKPGL YDMQQVLGLN
Length:270
Mass (Da):29,279
Last modified:October 3, 2006 - v1
Checksum:i92CC873EB4AD46F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000446 Genomic DNA. Translation: ABI38044.1.
RefSeqiYP_733101.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI38044; ABI38044; Shewmr4_0964.
GeneIDi4251615.
KEGGishe:Shewmr4_0964.
PATRICi23578406. VBISheSp133532_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000446 Genomic DNA. Translation: ABI38044.1 .
RefSeqi YP_733101.1. NC_008321.1.

3D structure databases

ProteinModelPortali Q0HLM3.
SMRi Q0HLM3. Positions 5-270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 60480.Shewmr4_0964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI38044 ; ABI38044 ; Shewmr4_0964 .
GeneIDi 4251615.
KEGGi she:Shewmr4_0964.
PATRICi 23578406. VBISheSp133532_1000.

Phylogenomic databases

eggNOGi COG0289.
HOGENOMi HOG000227153.
KOi K00215.
OMAi HTVWFAD.
OrthoDBi EOG6SV5DS.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci SSP60480:GI2N-994-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-4.

Entry informationi

Entry nameiDAPB_SHESM
AccessioniPrimary (citable) accession number: Q0HLM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3