Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0HLJ0

- SYL_SHESM

UniProt

Q0HLJ0 - SYL_SHESM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP60480:GI2N-1028-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Shewmr4_0997
    OrganismiShewanella sp. (strain MR-4)
    Taxonomic identifieri60480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008079: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_1000009427Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi60480.Shewmr4_0997.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0HLJ0.
    SMRiQ0HLJ0. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0HLJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEQYNPSEI EALVQKHWHD NKTFEVTEDA NKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARFQRLQG KNVLQPIGWD SFGLPAENAA INNKTAPAPW 100
    TYQNIEYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTASVNWCP NDETVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE 200
    ELLNDIDTLD GWPEQVKTMQ RNWIGRSEGV EMTFGVAGSD KSFDIYTTRP 250
    DTLMGVTYVA IAAGHPLAEL AAQTNPELAQ FIEECKNSTT SEADLATMEK 300
    RGVATGLYAI HPITGKQVPI WAANFVLMNY GTGAVMSVPG HDQRDYEFAK 350
    KYNLSIEAVI KPVDGELDIS EAAYTEKGVL FNSGEFDGLD FDGAFNAIAD 400
    KLVAEGKGKR QVNYRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPEDQLP 450
    VILPEDVVMD GIQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA 500
    RYCSPQADQM LDPTKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG 550
    LVNSNEPAKQ LLTQGMVLAD AFYYNNDKGA RVWVSPLDVV TTEKDDKGRV 600
    TKAIDKDGNE LVYTGMCKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP 650
    PELTLEWQES GVEGAHRFIK RLWKLASDYV AQDNSEALDV SKLTSEQKAL 700
    RREVHKTIAK VTDDIGRRQM FNTAVAAVME LMNHLQKAPQ TTGQDRAIIG 750
    EALTAVVRLL YPIIPHVSFT LWNELGNTNS IEDSQWPVVD ESALVEDSKL 800
    IVVQVNGKVR AKITVAADAD QASVEALGMA DEQVIKYLDG VTVRKVIYVP 850
    GKLLSIVAN 859
    Length:859
    Mass (Da):96,793
    Last modified:October 3, 2006 - v1
    Checksum:i20CEFE5EA167C298
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI38077.1.
    RefSeqiWP_011621789.1. NC_008321.1.
    YP_733134.1. NC_008321.1.

    Genome annotation databases

    EnsemblBacteriaiABI38077; ABI38077; Shewmr4_0997.
    GeneIDi4251035.
    KEGGishe:Shewmr4_0997.
    PATRICi23578474. VBISheSp133532_1033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI38077.1 .
    RefSeqi WP_011621789.1. NC_008321.1.
    YP_733134.1. NC_008321.1.

    3D structure databases

    ProteinModelPortali Q0HLJ0.
    SMRi Q0HLJ0. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 60480.Shewmr4_0997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI38077 ; ABI38077 ; Shewmr4_0997 .
    GeneIDi 4251035.
    KEGGi she:Shewmr4_0997.
    PATRICi 23578474. VBISheSp133532_1033.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSP60480:GI2N-1028-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-4.

    Entry informationi

    Entry nameiSYL_SHESM
    AccessioniPrimary (citable) accession number: Q0HLJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3