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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateUniRule annotation1
Binding sitei69SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Sitei175Important for catalytic activityUniRule annotation1
Active sitei177Proton donor/acceptorUniRule annotation1
Active sitei249NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:Shewmr4_1726
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000056631 – 342Beta-hexosaminidaseAdd BLAST342

Structurei

3D structure databases

ProteinModelPortaliQ0HJG7.
SMRiQ0HJG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 165Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248526.
KOiK01207.
OMAiHKETPRD.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ. 1 hit.
InterProiView protein in InterPro
IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00933. Glyco_hydro_3. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00775. GLYCOSYL_HYDROL_F3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HJG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLMLDLLS LDVSEAEAEM LRHPQVGGLI LFSRNFSSRE QLIALVQQIR
60 70 80 90 100
QIRPEILIAV DHEGGRVQRF REGFTLIPAM GDILPAAKGD MVLAKRWACE
110 120 130 140 150
LGFLMAIELL ACDIDLSFAP VLDLNGISQV IGKRSFSAKP DEVIALAQSF
160 170 180 190 200
IEGMAEAGMG AVGKHFPGHG SVAADSHIAQ PIDEREAEAI FNQDILPFKE
210 220 230 240 250
LIAKGKLSGI MPAHVIYPKV DPNPAGFSSY WLKQILRKEL GFNGVIFSDD
260 270 280 290 300
LGMKGAAFAG DYLGRAQAAL DAGCDMILVC NDNPGVMSLL NGFVWPAAAP
310 320 330 340
QHPASLLKPN AAQTAIALEN ASRWENAKQL AEQIQLAQQA KV
Length:342
Mass (Da):36,984
Last modified:October 3, 2006 - v1
Checksum:i70FF36B4A57C7073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI38800.1.
RefSeqiWP_011622500.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI38800; ABI38800; Shewmr4_1726.
KEGGishe:Shewmr4_1726.

Similar proteinsi

Entry informationi

Entry nameiNAGZ_SHESM
AccessioniPrimary (citable) accession number: Q0HJG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: September 27, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families