ID   CDD_SHESM               Reviewed;         296 AA.
AC   Q0HHI5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=Shewmr4_2411;
OS   Shewanella sp. (strain MR-4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60480;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J.,
RA   Tiedje J., Richardson P.;
RT   "Complete sequence of Shewanella sp. MR-4.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; CP000446; ABI39482.1; -; Genomic_DNA.
DR   RefSeq; YP_734539.1; -.
DR   GeneID; 4252982; -.
DR   GenomeReviews; CP000446_GR; Shewmr4_2411.
DR   KEGG; she:Shewmr4_2411; -.
DR   HOGENOM; Q0HHI5; -.
DR   OMA; Q0HHI5; FSPCGHC.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    296       Cytidine deaminase.
FT                                /FTId=PRO_1000068966.
FT   REGION       88     90       Substrate binding (By similarity).
FT   ACT_SITE    103    103       Proton donor (By similarity).
FT   METAL       101    101       Zinc; catalytic (By similarity).
FT   METAL       128    128       Zinc; catalytic (By similarity).
FT   METAL       131    131       Zinc; catalytic (By similarity).
SQ   SEQUENCE   296 AA;  32072 MW;  70803BA5B06A4F24 CRC64;
     MQDRFIRSIT QLPTPLADAL IPLLHQNFAG HIDAQQLAEL VQSSKMTEAE VLLALLPIAA
     ALAKPPISEF YVGAIAKGKS GDIYMGANLE LPGEALFHSV HAEQSAISHA WLSGESQIVD
     MIVNASPCGH CRQFMNELVE GGQIKIHLPS QDSHLLSYYL PYAFGPKDLN VQSPLLVKHE
     TEFALDSSDP MVIEALDHAG LSYAPYTQSY AAVVLETSDG ATYCGRYAEN AAFNPSMLPM
     QMALSNLTRH NRDFGEIRRA VLVESSQGKI SLVGATMDAL HAVAAIELEH IVVDPV
//