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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi394 – 401ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Shewmr4_2422
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

Q0HHH4:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalUniRule annotationAdd BLAST21
Transmembranei81 – 101HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei267 – 287HelicalUniRule annotationAdd BLAST21
Transmembranei296 – 316HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716541 – 601Lipid A export ATP-binding/permease protein MsbAAdd BLAST601

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0HHH4.
SMRiQ0HHH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 328ABC transmembrane type-1UniRule annotationAdd BLAST302
Domaini360 – 597ABC transporterUniRule annotationAdd BLAST238

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HHH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASPKDEMW TVFKRLLGYL KPMKGMFLLS VCGLIVYGLV DAAFISFIGP
60 70 80 90 100
FIDKGFSSST PAISNGIALP TSQGFHADNQ VLLMAPIVVI LMFSLRGFAN
110 120 130 140 150
FVSTYGISYM SARLIMDMRQ QVFEHYLSLP VSYMDKENTG NLISKVTFDT
160 170 180 190 200
EQIARASGSA LISIVRDGVT VIGMLGLMFY NSWKLSLCIL VIGPIMGLVI
210 220 230 240 250
TIVSRRFRKV SKQIQTAMGD VSAATEQMIK GHKNVLAFGG QETETARFAK
260 270 280 290 300
INDRNRHQNM KLAVAQAVSQ PLIMVIGSFA LAFVLYAASL DSMKADLTAG
310 320 330 340 350
TFATILGAMM AMLQPIKNLT RVNAEFQRGI AACTTVFELL DTLPESDTGT
360 370 380 390 400
YTVKRAKGNL RFDNVSFSYE GQERRALDKI DFEVTQGQTL ALVGRSGSGK
410 420 430 440 450
STIASLVTRF YTGLESGDIK LDDVSIYDYS LKSLRSQVAL VSQQVTLFND
460 470 480 490 500
TIANNIAYAY PGEATREQII QAATLAHAME FIEQLPEGLD TQVGENGVLL
510 520 530 540 550
SGGQRQRIAI ARAMLRDAPV LILDEATSAL DTESEKAIQQ GLDNLRQNRT
560 570 580 590 600
SVVIAHRLST IESADQILVV DQGRIVERGT HKSLLELGGM YAKLYQMQFG

S
Length:601
Mass (Da):65,770
Last modified:October 3, 2006 - v1
Checksum:iF9F6253FA6CC0630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI39493.1.
RefSeqiWP_011623176.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI39493; ABI39493; Shewmr4_2422.
KEGGishe:Shewmr4_2422.

Similar proteinsi

Entry informationi

Entry nameiMSBA_SHESM
AccessioniPrimary (citable) accession number: Q0HHH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families