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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSSP60480:GI2N-2743-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Shewmr4_2628
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008079: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthasePRO_1000049419Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi60480.Shewmr4_2628.

Structurei

3D structure databases

ProteinModelPortaliQ0HGW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HGW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKSQLVFA MVAGELSGDI LGAGLMAALQ KTHPNARFVG IGGPRMEALG
60 70 80 90 100
FESLFAMEEL AVMGIVEVLS RLPRLLHVRS SLIKSITELK PDCFIGIDAP
110 120 130 140 150
DFNIGLELKL KAQGIKTVHY VSPSVWAWRP KRIFKIAKAT NMVLSLLPFE
160 170 180 190 200
KAFYDKHQVP CTFVGHTLAD DIPLESDKAS ARQLLELDPD AEYLAILPGS
210 220 230 240 250
RGGELKQLAE PFVKAALLIK QQFPDIRFVT PLVNQKRREQ FEQALKAHAP
260 270 280 290 300
DLEIHMVEGK SREVMAAADG ILLASGTATL EAMLIKRPMV VAYRVSPLTY
310 320 330 340 350
QIAKTMMQVN RFSLPNLLAG RDVVPELIQH DCTPEKIAAA VGVELNRDFA
360 370 380
PIKAEFERLH QMLRCDASQK AAEAVLALVD AKDVN
Length:385
Mass (Da):42,423
Last modified:October 3, 2006 - v1
Checksum:iC508C087C9A77E78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI39699.1.
RefSeqiWP_011623380.1. NC_008321.1.
YP_734756.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI39699; ABI39699; Shewmr4_2628.
GeneIDi4253199.
KEGGishe:Shewmr4_2628.
PATRICi23582018. VBISheSp133532_2724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI39699.1.
RefSeqiWP_011623380.1. NC_008321.1.
YP_734756.1. NC_008321.1.

3D structure databases

ProteinModelPortaliQ0HGW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi60480.Shewmr4_2628.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI39699; ABI39699; Shewmr4_2628.
GeneIDi4253199.
KEGGishe:Shewmr4_2628.
PATRICi23582018. VBISheSp133532_2724.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciSSP60480:GI2N-2743-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-4.

Entry informationi

Entry nameiLPXB_SHESM
AccessioniPrimary (citable) accession number: Q0HGW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.