Reviewed, UniProtKB/Swiss-Prot Q0HFM7 (CYSC_SHESM)

Names and origin

Protein names

Recommended name:
    Adenylyl-sulfate kinase
    EC=2.7.1.25
Alternative name(s):
    APS kinase
    Adenosine-5'-phosphosulfate kinase
    ATP adenosine-5'-phosphosulfate 3'-phosphotransferase

Gene names

Name:	cysC
Ordered Locus Names:	Shewmr4_3069

Organism

Shewanella sp. (strain MR-4) [Complete proteome] [HAMAP]

Taxonomic identifier

60480 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylylsulfate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000009028
Regions
	Nucleotide binding	31 – 38	8	ATP By similarity
Sites
	Active site	105	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0HFM7-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 148EEE972C42B378	FASTA	205	22,323
	10 20 30 40 50 60 MSNIVWHQHS VDQAARAKLK GQNPVLLWFT GLSGAGKSTL AGALERALFE AGFHTYLLDG 70 80 90 100 110 120 DNVRHGLCKD LGFSVADRDE NLRRVGEVAK LMVDAGLVVL SAFISPTREE RDSIRARFPT 130 140 150 160 170 180 GQFIEVHVST PLSICEQRDP KGLYVKARRG EISNFTGISS PYEAPLSAEL TIDTSKGDLA 190 200 SQVRALIDYL TAIEVINPSR LTASA

References

[1]

"Complete sequence of Shewanella sp. MR-4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000446 Genomic DNA. Translation: ABI40140.1.
RefSeq	YP_735197.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4253640.
GenomeReviews	Gene locus Shewmr4_3069 in contig CP000446_GR.
KEGG	she:Shewmr4_3069.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0HFM7.
OMA	Q0HFM7. IVWHQHS.
Family and domain databases
HAMAP	MF_00065. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
ProDom	PD002350. APS_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00455. apsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_SHESM

Accession

Primary (citable) accession number: Q0HFM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)