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Q0HEX2

- GCSP_SHESM

UniProt

Q0HEX2 - GCSP_SHESM

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSSP60480:GI2N-3456-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Shewmr4_3329
    OrganismiShewanella sp. (strain MR-4)
    Taxonomic identifieri60480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008079: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000045613Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi60480.Shewmr4_3329.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0HEX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0HEX2-1 [UniParc]FASTAAdd to Basket

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    MTKQTLTQLE QHDLFLRRHI GPDSSQQQEM LNYVGAESLD DLTAQIVPES    50
    IRLSQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL 100
    RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
    EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
    VGPAHEAVNH ELFGALFQYS NRFGQITDFT DLFAELRAKN VIVTVAADIM 250
    ALVLLKSPGA MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
    IIGVSKDTRG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
    FHGPQGLKTI ASRINRFTDI LAAGLQAKGV SLVNNTWFDT ISIKGLDVAA 400
    VNARALAAEM NLRFDADGIV GVSLDETTLR TDIDALFDVI LGAGHGLDVA 450
    ALDAQIVAQG SQSIPEALVR QDAILTHPTF NRYQSETEMM RYIKRLESKD 500
    LALNYSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFCPL DQAKGYTQLI 550
    EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIRKYHES RGQAHRNICL 600
    IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKAKA AEVAENLSCI 650
    MITYPSTHGV YEESIREICN IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKPGRESDNN 750
    GAVSAAPYGS AGILPISWMY IKLLGSNGLK KSTQTALLNA NYVMKKLSEH 800
    YPVLFRGRND RVAHECIIDL RPIKEASGVT EMDIAKRLND YGFHAPTMSF 850
    PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVEAGE WPADNNPLHN 900
    APHTMADIMD SAFDSRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
    LFCACVPLSD YE 962
    Length:962
    Mass (Da):104,781
    Last modified:October 3, 2006 - v1
    Checksum:iF794F9194D05BB66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI40395.1.
    RefSeqiWP_011624063.1. NC_008321.1.
    YP_735452.1. NC_008321.1.

    Genome annotation databases

    EnsemblBacteriaiABI40395; ABI40395; Shewmr4_3329.
    GeneIDi4253895.
    KEGGishe:Shewmr4_3329.
    PATRICi23583483. VBISheSp133532_3449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000446 Genomic DNA. Translation: ABI40395.1 .
    RefSeqi WP_011624063.1. NC_008321.1.
    YP_735452.1. NC_008321.1.

    3D structure databases

    ProteinModelPortali Q0HEX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 60480.Shewmr4_3329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI40395 ; ABI40395 ; Shewmr4_3329 .
    GeneIDi 4253895.
    KEGGi she:Shewmr4_3329.
    PATRICi 23583483. VBISheSp133532_3449.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SSP60480:GI2N-3456-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-4.

    Entry informationi

    Entry nameiGCSP_SHESM
    AccessioniPrimary (citable) accession number: Q0HEX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3