SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0HEX2

- GCSP_SHESM

UniProt

Q0HEX2 - GCSP_SHESM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Shewmr4_3329
Organism
Shewanella sp. (strain MR-4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSP60480:GI2N-3456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Shewmr4_3329
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008079: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi60480.Shewmr4_3329.

Structurei

3D structure databases

ProteinModelPortaliQ0HEX2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HEX2-1 [UniParc]FASTAAdd to Basket

« Hide

MTKQTLTQLE QHDLFLRRHI GPDSSQQQEM LNYVGAESLD DLTAQIVPES    50
IRLSQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL 100
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
VGPAHEAVNH ELFGALFQYS NRFGQITDFT DLFAELRAKN VIVTVAADIM 250
ALVLLKSPGA MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
IIGVSKDTRG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
FHGPQGLKTI ASRINRFTDI LAAGLQAKGV SLVNNTWFDT ISIKGLDVAA 400
VNARALAAEM NLRFDADGIV GVSLDETTLR TDIDALFDVI LGAGHGLDVA 450
ALDAQIVAQG SQSIPEALVR QDAILTHPTF NRYQSETEMM RYIKRLESKD 500
LALNYSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFCPL DQAKGYTQLI 550
EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIRKYHES RGQAHRNICL 600
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKAKA AEVAENLSCI 650
MITYPSTHGV YEESIREICN IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKPGRESDNN 750
GAVSAAPYGS AGILPISWMY IKLLGSNGLK KSTQTALLNA NYVMKKLSEH 800
YPVLFRGRND RVAHECIIDL RPIKEASGVT EMDIAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVEAGE WPADNNPLHN 900
APHTMADIMD SAFDSRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
LFCACVPLSD YE 962
Length:962
Mass (Da):104,781
Last modified:October 3, 2006 - v1
Checksum:iF794F9194D05BB66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000446 Genomic DNA. Translation: ABI40395.1.
RefSeqiWP_011624063.1. NC_008321.1.
YP_735452.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI40395; ABI40395; Shewmr4_3329.
GeneIDi4253895.
KEGGishe:Shewmr4_3329.
PATRICi23583483. VBISheSp133532_3449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000446 Genomic DNA. Translation: ABI40395.1 .
RefSeqi WP_011624063.1. NC_008321.1.
YP_735452.1. NC_008321.1.

3D structure databases

ProteinModelPortali Q0HEX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 60480.Shewmr4_3329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI40395 ; ABI40395 ; Shewmr4_3329 .
GeneIDi 4253895.
KEGGi she:Shewmr4_3329.
PATRICi 23583483. VBISheSp133532_3449.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SSP60480:GI2N-3456-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-4.

Entry informationi

Entry nameiGCSP_SHESM
AccessioniPrimary (citable) accession number: Q0HEX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi