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Q0HEK4 (PUR7_SHESM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:Shewmr4_3447
OrganismShewanella sp. (strain MR-4) [Complete proteome] [HAMAP]
Taxonomic identifier60480 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000117854

Sequences

Sequence LengthMass (Da)Tools
Q0HEK4 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 825235A4E6FB1B2B

FASTA36740,854
        10         20         30         40         50         60 
MSLADSVLAV NNDLPIRTDN PVHSGKVRSV YWLTDADSRR LIQTKGYNVP EDTPLAIMVI 

        70         80         90        100        110        120 
SDRISAFDCI FHGEGGLKGI PGKGAALNAI SNHWFKLFAE NGLADSHILD IPHPFVWIVQ 

       130        140        150        160        170        180 
KARPIKVEAI CRQYITGSMW RAYSKGERVF CGITLPEGLE KDQKLPDLLI TPSTKGILTG 

       190        200        210        220        230        240 
IPGVPAQDDV NISRSDIEAN YQAFGFEKVE DIDLYEKLLK DGFKVIAKAL ADLDQVFVDT 

       250        260        270        280        290        300 
KFEFGYVTDK NGNSKLIYMD EVGTPDSSRI WDGAAYRDGK ILENSKEGFR QFLLNHFPDP 

       310        320        330        340        350        360 
DILLNKDRMP EREALARDNA LPLEAMMDVS RTYTGIAEKV TGAAIPLPAN PKADIIKILR 


EEYDLIV

« Hide

References

[1]"Complete sequence of Shewanella sp. MR-4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MR-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000446 Genomic DNA. Translation: ABI40513.1.
RefSeqYP_735570.1. NC_008321.1.

3D structure databases

ProteinModelPortalQ0HEK4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0HEK4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4254013.
GenomeReviewsGene locus Shewmr4_3447 in contig CP000446_GR.
KEGGshe:Shewmr4_3447.
PATRIC23583733. VBISheSp133532_3574.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHBG555040.
OMASSRIWDG.
ProtClustDBPRK13960.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_SHESM
AccessionPrimary (citable) accession number: Q0HEK4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 3, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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