Q0HE40 (KGUA_SHESM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Shewmr4_3613

Organism

Shewanella sp. (strain MR-4) [Complete proteome] [HAMAP]

Taxonomic identifier

60480 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266398
Regions
	Domain	5 – 184	180	Guanylate kinase-like
	Nucleotide binding	12 – 19	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0HE40 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 1D7E427CAE2CEC53	FASTA	207	23,024
	10 20 30 40 50 60 MTARGNLFIV SAPSGAGKSS LISALLKDKP ADMQVSVSHT TRAPRPGEVN GQHYHFVNVE 70 80 90 100 110 120 EFKALIEQNA FFEWAEVFGN YYGTSRHVIE HTLTQGIDVF LDIDWQGAQQ VKAVMPEAIG 130 140 150 160 170 180 VFILPPSRDE LERRLTGRGQ DSQEVIASRM AQAVSEMSHY KEYDFIIVND DFDTALADMR 190 200 AIIRSQRLTG ASQIHAQNDM LNDLLAG

References

[1]

"Complete sequence of Shewanella sp. MR-4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K., Konstantinidis K., Klappenbach J., Tiedje J., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000446 Genomic DNA. Translation: ABI40677.1.
RefSeq	YP_735734.1. NC_008321.1.
3D structure databases
ProteinModelPortal	Q0HE40.
SMR	Q0HE40. Positions 3-206.
ModBase	Search...
Protein-protein interaction databases
STRING	60480.Shewmr4_3613.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABI40677; ABI40677; Shewmr4_3613.
GeneID	4254177.
KEGG	she:Shewmr4_3613.
PATRIC	23584089. VBISheSp133532_3744.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037638.
KO	K00942.
OMA	FVIINEL.
ProtClustDB	PRK00300.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_SHESM

Accession

Primary (citable) accession number: Q0HE40

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program