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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:Shewmr4_3788
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000494611 – 807Glycerol-3-phosphate acyltransferaseAdd BLAST807

Structurei

3D structure databases

ProteinModelPortaliQ0HDL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi308 – 313HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0HDL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKQDSLWLK SLRWIQKHLV HTIVVPQDPF ADLNLDASRP LAYVMKTESL
60 70 80 90 100
SDIAALSEIT TKLGLPSPYE PLVVNGVVAP RVVCLEGRKP LFGERASNEP
110 120 130 140 150
FLECFMRLLA VHKEKPELDI QLVPVSLYWG RTPGKEDDTM KAAVLERENP
160 170 180 190 200
TWLRKCLMIL FLGRHNFVQF SNAVSLRYMA DEHGTDMGIA HKLARVARVH
210 220 230 240 250
FRRQRKVMTG PVLPNRQAMF HSLLKSESLR KAIQEEAASK KISETQARET
260 270 280 290 300
AIEYLDEIAA NYSDSLVRIA ERFLTWLWNK LYSGINIKGA EQIRQLHHDG
310 320 330 340 350
HEIVYVPCHR SHMDYLLLSY ILYYQGMVPP HIAAGINLNF WPAGPLFRRG
360 370 380 390 400
GAFFIRRSFN GNKLYTAVFR EYLDQLFAKG YSVEYFSEGG RSRTGRLLAP
410 420 430 440 450
KTGMIAMTIN SVLRGIERPV TLVPVYLGYD HVMEVATYHK ELSGKKKQKE
460 470 480 490 500
SVWQVFGAIR KLGNFGQGYV NFGEPITLQN FLNETAPNWR AEVADDPEQK
510 520 530 540 550
PTWLTPAVNV LANRVMTRIN DAAAASSITL TSLVLLASEQ NALERCLLER
560 570 580 590 600
QLDLYLTLLK RVPYTSFTSV AEGDGKHLVQ QGLELNKFSI NADPLGEIVS
610 620 630 640 650
IDANQAISMT YYRNNIIHLF IIPSLIASCL TNNKQISRAH ILGIVSDFYP
660 670 680 690 700
LLKAELFMGI KDLPSYVNQV LDLFIEQGLV QESDTLSVVT EHTSQMLLLA
710 720 730 740 750
GSVSETLQRY AIIFNLLAHR PKMERSELES ESHLLAQRLG ALHGITAPEF
760 770 780 790 800
YDKKLYNTLS VKLKELGYFS EKEDKSDVER IRDQANSLLR ASVRQTIVAS

VTAEHIV
Length:807
Mass (Da):91,353
Last modified:October 3, 2006 - v1
Checksum:i788D7977A8BF74A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI40851.1.
RefSeqiWP_011624509.1. NC_008321.1.

Genome annotation databases

EnsemblBacteriaiABI40851; ABI40851; Shewmr4_3788.
KEGGishe:Shewmr4_3788.
PATRICi23584461. VBISheSp133532_3927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA. Translation: ABI40851.1.
RefSeqiWP_011624509.1. NC_008321.1.

3D structure databases

ProteinModelPortaliQ0HDL6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI40851; ABI40851; Shewmr4_3788.
KEGGishe:Shewmr4_3788.
PATRICi23584461. VBISheSp133532_3927.

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_SHESM
AccessioniPrimary (citable) accession number: Q0HDL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.