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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Copper ABy similarity1
Metal bindingi224Copper ABy similarity1
Metal bindingi228Copper ABy similarity1
Metal bindingi232Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 43Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 80Mitochondrial matrixSequence analysisAdd BLAST16
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 255Mitochondrial intermembraneSequence analysisAdd BLAST154

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
ChainiPRO_000027114217 – 255Cytochrome c oxidase subunit 2Add BLAST239

Structurei

3D structure databases

ProteinModelPortaliQ0H8Y7
SMRiQ0H8Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ0H8Y7
KOiK02261
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0H8Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNLFPPFGA NTAIFNDAPQ PWQVGFQDGA SPTQEGITEL HDSIFFYLVI
60 70 80 90 100
ICFGVLWVLS SVIVNFNSNK SQLVYKYANH GTLIELIWTI TPALVLIAIA
110 120 130 140 150
FPSFKLLYLM DEVISPSMTV KVAGHQWYWS AEYSDFINED GESIEFDSYM
160 170 180 190 200
VPETDLEDGQ LRLLEVDNRM VVPIDTHIRF IVTGADVIHD FAVPSLGLKI
210 220 230 240 250
DAVPGRLNQT SVLIEREGVF YGQCSEICGV YHGFMPIAIE AVTPEKYLAW

IDSQA
Length:255
Mass (Da):28,613
Last modified:October 3, 2006 - v1
Checksum:i23B1FCAF85401052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157700 Genomic DNA Translation: AAZ67008.1
AACP01000278 Genomic DNA No translation available.
RefSeqiYP_762685.1, NC_008368.1

Genome annotation databases

GeneIDi4308289
KEGGiuma:UsmafMp05

Similar proteinsi

Entry informationi

Entry nameiCOX2_USTMA
AccessioniPrimary (citable) accession number: Q0H8Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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