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Q0H8Y4

- COX1_USTMA

UniProt

Q0H8Y4 - COX1_USTMA

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Iron (heme A axial ligand)By similarity
    Metal bindingi240 – 2401Copper BBy similarity
    Metal bindingi244 – 2441Copper BBy similarity
    Metal bindingi289 – 2891Copper BBy similarity
    Metal bindingi290 – 2901Copper BBy similarity
    Metal bindingi375 – 3751Iron (heme A3 axial ligand)By similarity
    Metal bindingi377 – 3771Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Encoded oniMitochondrion
    OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
    Taxonomic identifieri237631 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
    ProteomesiUP000000561: Mitochondrion, UP000000561: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: InterPro
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Cytochrome c oxidase subunit 1PRO_0000271141Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity
    Lipidationi318 – 3181N6-myristoyl lysineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Structurei

    3D structure databases

    ProteinModelPortaliQ0H8Y4.
    SMRiQ0H8Y4. Positions 3-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02256.
    OrthoDBiEOG72C58S.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0H8Y4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRWLYSTNA KDIGTLYLIF AVFAAMIGTA FSVLIRMELA APGVQYLNGD    50
    HQLYNVIITA HAFVMIFFMV MPAMVGGFGN YLVPVMIGAP DMAFPRLNNI 100
    SFWLLPPSLI LLLASAFVEQ GAGTGWTVYP PLSGLQSHSG GSVDLAIFSL 150
    HLSGISSMLG AMNFITTVLN MRNPGMTLHK LPLFVWAIFV TAILLLLSLP 200
    VLAGAITMLL TDRNFNTSFY DPAGGGDPIL YQHLFWFFGH PEVYILIIPG 250
    FGMVSHIVSA FSGKPVFGYL GMVYAMFSIG ILGFLVWSHH MYAVGLDVDT 300
    RAYFTAATMI IAVPTGIKIF SWLATLYGGS LRITTPMLFA LGFIALFTIG 350
    GLTGVILANA SLDVALHDTY YVVAHFHYVL SMGAVFALFG GFYFWTPKII 400
    GKTFNENLGR IHFWTLFVGV NLTFFPQHFL GLGGMPRRIP DYPDAFAAWN 450
    AISSFGSLVS VVATALFGYI IYDILVNGKP VDANPWAVPA FFQSTPEFWM 500
    ESHTASSLEW ALESPTPFHS FNMLPVQS 528
    Length:528
    Mass (Da):57,899
    Last modified:October 3, 2006 - v1
    Checksum:i7381FC2EB2788C66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ157700 Genomic DNA. Translation: AAZ67011.1.
    AACP01000277 Genomic DNA. No translation available.
    AACP01000278 Genomic DNA. No translation available.
    RefSeqiYP_762688.1. NC_008368.1.

    Genome annotation databases

    GeneIDi4308276.
    KEGGiuma:UsmafMp08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ157700 Genomic DNA. Translation: AAZ67011.1 .
    AACP01000277 Genomic DNA. No translation available.
    AACP01000278 Genomic DNA. No translation available.
    RefSeqi YP_762688.1. NC_008368.1.

    3D structure databases

    ProteinModelPortali Q0H8Y4.
    SMRi Q0H8Y4. Positions 3-521.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4308276.
    KEGGi uma:UsmafMp08.

    Phylogenomic databases

    KOi K02256.
    OrthoDBi EOG72C58S.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Annotation of mitochondrial genome of Ustilago maydis and comparative analysis of basidiomycete mtDNAs."
      Kennell J.C., Boehmer C.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.
    2. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
      Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
      , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
      Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.

    Entry informationi

    Entry nameiCOX1_USTMA
    AccessioniPrimary (citable) accession number: Q0H8Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3