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Q0H8C4

- VP6_ROTB2

UniProt

Q0H8C4 - VP6_ROTB2

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Status
Reviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
    Taxonomic identifieri348136 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008656: Genome

    Subcellular locationi

    Virion By similarity
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.Curated

    GO - Cellular componenti

    1. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Intermediate capsid protein VP6PRO_0000369860Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR020245. Rotavirus_B_VP6.
    [Graphical view]
    ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q0H8C4-1 [UniParc]FASTAAdd to Basket

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    MDLIETINAV VELQHRVRNL SPNTNIYQDG QTTINDYNAI ASRCNGKVYN    50
    LRDQIAQLSP FQVHMPVIPI STILSTDDHE TMSAGIESLF DVLAAAIRTE 100
    GSRQNRAVVT KSIEPEVLKA VLDIGIRSQF SENPYANMLQ VDTAKMEQQL 150
    EPIDDPLASQ KINMLAAGGA TNNTGGGYHA LVGRATGKTG VVTIIQGRPG 200
    AVTFNLNMKV PCSGVLSLTL LPAPGVIQLS LGNQPPNNIP VHAECVDVST 250
    VFAEGDIVIR FELAGRVVGN ANKLGTLNFP LCDRISITIE PWNANKQNNA 300
    NANFNNWPAG TAQRQPTVSL FVNIINASSL IDYETHSKYL AGATYLMGTT 350
    FSEDSFIASP PNVVWTMSSL LSGAPPQYIH WTRKIACMIA AFSCKI 396
    Length:396
    Mass (Da):42,822
    Last modified:October 3, 2006 - v1
    Checksum:i4A46733834DF59F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ168033 Genomic RNA. Translation: ABA60393.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ168033 Genomic RNA. Translation: ABA60393.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020245. Rotavirus_B_VP6.
    [Graphical view ]
    ProDomi PD042229. Rotavirus_B_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh."
      Alam M.M., Kobayashi N., Ishino M., Ahmed M.S., Ahmed M.U., Paul S.K., Muzumdar B.K., Hussain Z., Wang Y.H., Naik T.N.
      Arch. Virol. 152:199-208(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP6_ROTB2
    AccessioniPrimary (citable) accession number: Q0H8C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3