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Q0H8C4 (VP6_ROTB2) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

Subunit structure

Homotrimer By similarity. Interacts with VP2 By similarity.

Subcellular location

Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.

Sequence similarities

Belongs to the rotavirus VP6 family.

Ontologies

Keywords
   Cellular componentCapsid protein
Intermediate capsid protein
Virion
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentviral intermediate capsid

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Intermediate capsid protein VP6
PRO_0000369860

Sequences

Sequence LengthMass (Da)Tools
Q0H8C4 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 4A46733834DF59F3

FASTA39642,822
        10         20         30         40         50         60 
MDLIETINAV VELQHRVRNL SPNTNIYQDG QTTINDYNAI ASRCNGKVYN LRDQIAQLSP 

        70         80         90        100        110        120 
FQVHMPVIPI STILSTDDHE TMSAGIESLF DVLAAAIRTE GSRQNRAVVT KSIEPEVLKA 

       130        140        150        160        170        180 
VLDIGIRSQF SENPYANMLQ VDTAKMEQQL EPIDDPLASQ KINMLAAGGA TNNTGGGYHA 

       190        200        210        220        230        240 
LVGRATGKTG VVTIIQGRPG AVTFNLNMKV PCSGVLSLTL LPAPGVIQLS LGNQPPNNIP 

       250        260        270        280        290        300 
VHAECVDVST VFAEGDIVIR FELAGRVVGN ANKLGTLNFP LCDRISITIE PWNANKQNNA 

       310        320        330        340        350        360 
NANFNNWPAG TAQRQPTVSL FVNIINASSL IDYETHSKYL AGATYLMGTT FSEDSFIASP 

       370        380        390 
PNVVWTMSSL LSGAPPQYIH WTRKIACMIA AFSCKI 

« Hide

References

[1]"Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh."
Alam M.M., Kobayashi N., Ishino M., Ahmed M.S., Ahmed M.U., Paul S.K., Muzumdar B.K., Hussain Z., Wang Y.H., Naik T.N.
Arch. Virol. 152:199-208(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ168033 Genomic RNA. Translation: ABA60393.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameVP6_ROTB2
AccessionPrimary (citable) accession number: Q0H8C4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 3, 2006
Last modified: October 16, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families