Q0H8C4 (VP6_ROTB2) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 19. History...
Names and origin
|Protein names||Recommended name:|
Intermediate capsid protein VP6
|Organism||Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219)) [Complete proteome]|
|Taxonomic identifier||348136 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › unclassified rotaviruses|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||396 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.
Homotrimer By similarity. Interacts with VP2 By similarity.
Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.
Belongs to the rotavirus VP6 family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 396||396||Intermediate capsid protein VP6||PRO_0000369860|
|||"Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh."|
Alam M.M., Kobayashi N., Ishino M., Ahmed M.S., Ahmed M.U., Paul S.K., Muzumdar B.K., Hussain Z., Wang Y.H., Naik T.N.
Arch. Virol. 152:199-208(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|DQ168033 Genomic RNA. Translation: ABA60393.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR020245. Rotavirus_B_VP6. |
|ProDom||PD042229. Rotavirus_B_VP6. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: Q0H8C4|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families