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Q0H8C4

- VP6_ROTB2

UniProt

Q0H8C4 - VP6_ROTB2

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Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Status
Reviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Taxonomic identifieri348136 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008656: Genome

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential).Curated

GO - Cellular componenti

  1. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Intermediate capsid protein VP6PRO_0000369860Add
BLAST

Interactioni

Subunit structurei

Homotrimer. Interacts with VP2.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.Curated

Family and domain databases

InterProiIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q0H8C4 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDLIETINAV VELQHRVRNL SPNTNIYQDG QTTINDYNAI ASRCNGKVYN
60 70 80 90 100
LRDQIAQLSP FQVHMPVIPI STILSTDDHE TMSAGIESLF DVLAAAIRTE
110 120 130 140 150
GSRQNRAVVT KSIEPEVLKA VLDIGIRSQF SENPYANMLQ VDTAKMEQQL
160 170 180 190 200
EPIDDPLASQ KINMLAAGGA TNNTGGGYHA LVGRATGKTG VVTIIQGRPG
210 220 230 240 250
AVTFNLNMKV PCSGVLSLTL LPAPGVIQLS LGNQPPNNIP VHAECVDVST
260 270 280 290 300
VFAEGDIVIR FELAGRVVGN ANKLGTLNFP LCDRISITIE PWNANKQNNA
310 320 330 340 350
NANFNNWPAG TAQRQPTVSL FVNIINASSL IDYETHSKYL AGATYLMGTT
360 370 380 390
FSEDSFIASP PNVVWTMSSL LSGAPPQYIH WTRKIACMIA AFSCKI
Length:396
Mass (Da):42,822
Last modified:October 3, 2006 - v1
Checksum:i4A46733834DF59F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ168033 Genomic RNA. Translation: ABA60393.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ168033 Genomic RNA. Translation: ABA60393.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR020245. Rotavirus_B_VP6.
[Graphical view ]
ProDomi PD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh."
    Alam M.M., Kobayashi N., Ishino M., Ahmed M.S., Ahmed M.U., Paul S.K., Muzumdar B.K., Hussain Z., Wang Y.H., Naik T.N.
    Arch. Virol. 152:199-208(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP6_ROTB2
AccessioniPrimary (citable) accession number: Q0H8C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3