Q0H8C3 (VP7_ROTB2) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 30. History...
Names and origin
|Protein names||Recommended name:|
Outer capsid glycoprotein VP7
|Organism||Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219)) [Complete proteome]|
|Taxonomic identifier||348136 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › unclassified rotaviruses|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||258 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.
Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.
Virion Potential. Host rough endoplasmic reticulum membrane; Single-pass membrane protein; Lumenal side Potential. Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.
Belongs to the rotavirus VP7 family.
|Cellular component||Host endoplasmic reticulum|
|Molecular function||Capsid protein|
Outer capsid protein
T=13 icosahedral capsid protein
|Technical term||Complete proteome|
|Gene Ontology (GO)|
|Cellular_component||T=13 icosahedral viral capsid|
Inferred from electronic annotation. Source: UniProtKB-KWhost cell rough endoplasmic reticulum membrane
Inferred from electronic annotation. Source: UniProtKB-SubCellintegral to membrane
Inferred from electronic annotation. Source: UniProtKB-KWviral outer capsid
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|||"Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh."|
Alam M.M., Kobayashi N., Ishino M., Ahmed M.S., Ahmed M.U., Paul S.K., Muzumdar B.K., Hussain Z., Wang Y.H., Naik T.N.
Arch. Virol. 152:199-208(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|DQ168034 Genomic RNA. Translation: ABA60394.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR008818. Rotavirus_VP7. |
|Pfam||PF05868. Rotavirus_VP7. 1 hit. |
|Accession||Primary (citable) accession number: Q0H8C3|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families