ID   NSP3_ROTB2              Reviewed;         262 AA.
AC   Q0H8C1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Non-structural protein 3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NSP3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=NCVP4 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=Non-structural RNA-binding protein 34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NS34 {ECO:0000255|HAMAP-Rule:MF_04090};
OS   Rotavirus X (isolate RVX/Human/Bangladesh/NADRV-B219/2002/GXP[X]) (RV
OS   ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus.
OX   NCBI_TaxID=348136;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16900303; DOI=10.1007/s00705-006-0831-y;
RA   Alam M.M., Kobayashi N., Ishino M., Ahmed M.S., Ahmed M.U., Paul S.K.,
RA   Muzumdar B.K., Hussain Z., Wang Y.H., Naik T.N.;
RT   "Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in
RT   a sporadic case of adult diarrhea in Bangladesh.";
RL   Arch. Virol. 152:199-208(2007).
CC   -!- FUNCTION: May play a role in stimulating the translation of viral
CC       mRNAs. {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SIMILARITY: Belongs to the rotavirus NSP3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04090}.
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DR   EMBL; DQ168036; ABA60396.1; -; Genomic_RNA.
DR   SMR; Q0H8C1; -.
DR   IntAct; Q0H8C1; 1.
DR   Proteomes; UP000174021; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   CDD; cd20714; NSP3_rotavirus; 1.
DR   HAMAP; MF_04090; ROTA_NSP3; 1.
DR   InterPro; IPR002873; Rotavirus_NSP3.
PE   3: Inferred from homology;
KW   Coiled coil; Host cytoplasm; RNA-binding; Translation regulation.
FT   CHAIN           1..262
FT                   /note="Non-structural protein 3"
FT                   /id="PRO_0000369849"
FT   REGION          226..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          138..179
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04090"
SQ   SEQUENCE   262 AA;  29987 MW;  76B1D982F1FDCF0B CRC64;
     MAELVCDALA TLTRNTYGNN DESAKFCRMF RAMIRDSGLY SNIENWRAAF YRDRLPKRMS
     HSTVSIQLDN LEREVLKIRA EGFCQGYTRK ERTLNAFDLG DDGKGNTIIK PTTHLSSIIL
     QNSYNSAFKL PKIPDGLLEK TRCELEEEKK NNDVLKQKIK ELENTISQLE NFENEAKASE
     FVLEHLKFTN ESLRIQRDEA QICLVGLCNK FGLQCEIDNS IRVTESDKKG KRKGRKNRRT
     EVSFGAPGHN LTDQINALSD VE
//