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Reviewed, UniProtKB/Swiss-Prot Q96PZ7 (CSMD1_HUMAN)

Last modified November 25, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    CUB and sushi domain-containing protein 1
Alternative name(s):
    CUB and sushi multiple domains protein 1
Gene names
Name: CSMD1
Synonyms: KIAA1890
ORF Names: UNQ5952/PRO19863
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length3565 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Potential suppressor of squamous cell carcinomas.

Subcellular location

Membrane; Single-pass type I membrane proteinPotential.

Tissue specificity

Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain.

Involvement in disease

Defects in CSMD1 may be a cause of oral and oropharyngeal squamous cell carcinomas (OSCCs). Ref.6 and Ref.7 are however in disagreement: while Ref.7 considers CSMD1 as a strong candidate for OSCCs, Ref.6 thinks it is not.

Sequence similarities

Belongs to the CSMD family.

Contains 14 CUB domains.

Contains 28 Sushi (CCP/SCR) domains.

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Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Sushi
Transmembrane
   PTMGlycoprotein
   Technical term3D-structure

Gene Ontology (GO)

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96PZ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96PZ7-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     2620-2677: Missing.
     2976-3094: Missing.
Isoform 3 (identifier: Q96PZ7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2082-2110: AYELQNCPDPPPFQNGYMINSDYSVGQSV → GGSGNIGPAFPCLDTPFQARCQGEERTFN
     2111-3565: Missing.
Notes: No experimental confirmation available.
Isoform 4 (identifier: Q96PZ7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2013-2013: A → K
     2014-3565: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 35653539CUB and sushi domain-containing protein 1
PRO_0000021025

Regions

Topological domain27 – 34883462Extracellular Potential
Transmembrane3489 – 350921 Potential
Topological domain3510 – 356556Cytoplasmic Potential
Domain32 – 140109CUB 1
Domain143 – 20462Sushi 1
Domain208 – 312105CUB 2
Domain347 – 40963Sushi 2
Domain412 – 523112CUB 3
Domain526 – 58358Sushi 3
Domain585 – 693109CUB 4
Domain696 – 75762Sushi 4
Domain759 – 867109CUB 5
Domain872 – 92958Sushi 5
Domain931 – 1041111CUB 6
Domain1044 – 110360Sushi 6
Domain1105 – 1213109CUB 7
Domain1216 – 127661Sushi 7
Domain1278 – 1387110CUB 8
Domain1390 – 145061Sushi 8
Domain1452 – 1560109CUB 9
Domain1563 – 162462Sushi 9
Domain1626 – 1734109CUB 10
Domain1740 – 180162Sushi 10
Domain1803 – 1911109CUB 11
Domain1914 – 197360Sushi 11
Domain1975 – 2083109CUB 12
Domain2086 – 214560Sushi 12
Domain2147 – 2258112CUB 13
Domain2257 – 231862Sushi 13
Domain2320 – 2431112CUB 14
Domain2431 – 249363Sushi 14
Domain2494 – 255562Sushi 15
Domain2556 – 262065Sushi 16
Domain2621 – 267858Sushi 17
Domain2679 – 273658Sushi 18
Domain2737 – 279458Sushi 19
Domain2795 – 285763Sushi 20
Domain2858 – 291558Sushi 21
Domain2919 – 297658Sushi 22
Domain2977 – 303559Sushi 23
Domain3036 – 309560Sushi 24
Domain3096 – 315358Sushi 25
Domain3154 – 321158Sushi 26
Domain3215 – 327359Sushi 27
Domain3274 – 333360Sushi 28

Amino acid modifications

Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation5881N-linked (GlcNAc...) Potential
Glycosylation6871N-linked (GlcNAc...) Potential
Glycosylation9561N-linked (GlcNAc...) Potential
Glycosylation10161N-linked (GlcNAc...) Potential
Glycosylation10351N-linked (GlcNAc...) Potential
Glycosylation11851N-linked (GlcNAc...) Potential
Glycosylation11981N-linked (GlcNAc...) Potential
Glycosylation14001N-linked (GlcNAc...) Potential
Glycosylation14551N-linked (GlcNAc...) Potential
Glycosylation15731N-linked (GlcNAc...) Potential
Glycosylation16451N-linked (GlcNAc...) Potential
Glycosylation17931N-linked (GlcNAc...) Potential
Glycosylation18061N-linked (GlcNAc...) Potential
Glycosylation18831N-linked (GlcNAc...) Potential
Glycosylation20191N-linked (GlcNAc...) Potential
Glycosylation21501N-linked (GlcNAc...) Potential
Glycosylation21551N-linked (GlcNAc...) Potential
Glycosylation21881N-linked (GlcNAc...) Potential
Glycosylation23591N-linked (GlcNAc...) Potential
Glycosylation23951N-linked (GlcNAc...) Potential
Glycosylation24011N-linked (GlcNAc...) Potential
Glycosylation24461N-linked (GlcNAc...) Potential
Glycosylation24711N-linked (GlcNAc...) Potential
Glycosylation25041N-linked (GlcNAc...) Potential
Glycosylation26061N-linked (GlcNAc...) Potential
Glycosylation27511N-linked (GlcNAc...) Potential
Glycosylation27621N-linked (GlcNAc...) Potential
Glycosylation27961N-linked (GlcNAc...) Potential
Glycosylation28951N-linked (GlcNAc...) Potential
Glycosylation29641N-linked (GlcNAc...) Potential
Glycosylation30231N-linked (GlcNAc...) Potential
Glycosylation30571N-linked (GlcNAc...) Potential
Glycosylation31061N-linked (GlcNAc...) Potential
Glycosylation32291N-linked (GlcNAc...) Potential
Glycosylation32611N-linked (GlcNAc...) Potential
Glycosylation33401N-linked (GlcNAc...) Potential
Glycosylation33801N-linked (GlcNAc...) Potential
Glycosylation33871N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 58 By similarity
Disulfide bond145 ↔ 185 By similarity
Disulfide bond171 ↔ 202 By similarity
Disulfide bond208 ↔ 234 By similarity
Disulfide bond349 ↔ 390 By similarity
Disulfide bond376 ↔ 407 By similarity