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Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotationCombined sources1
Metal bindingi148ZincUniRule annotationCombined sources1
Metal bindingi183ZincUniRule annotationCombined sources1
Metal bindingi186ZincUniRule annotation1
Metal bindingi186Zinc; via pros nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotationCombined sources, Nucleotide-binding, ZincUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:BTN44_12945Imported, EP54_10835Imported, EQ90_06730Imported, ERS072840_01851Imported, RK61_06985Imported, RK64_11250Imported, RK68_01595Imported, RK73_08120Imported, RL01_14270Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000035151 Componenti: Chromosome
  • UP000035281 Componenti: Chromosome
  • UP000035463 Componenti: Chromosome
  • UP000236484 Componenti: Chromosome
  • UP000035521 Componenti: Chromosome
  • UP000035452 Componenti: Chromosome
  • UP000069800 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5323

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E2IX-ray2.01A1-199[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0H0G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY
60 70 80 90 100
HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI
110 120 130 140 150
VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS
160 170 180 190
SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL
Length:199
Mass (Da):22,214
Last modified:October 3, 2006 - v1
Checksum:iC1EC76B7C5645909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ384605 Genomic DNA Translation: ABD37699.1
CP018629 Genomic DNA Translation: AUS76078.1
CP026957 Genomic DNA Translation: AVG53929.1
CP026960 Genomic DNA Translation: AVG58446.1
CP026961 Genomic DNA Translation: AVG60027.1
CP026962 Genomic DNA Translation: AVG64709.1
CP026964 Genomic DNA Translation: AVG66623.1
FGEC01000013 Genomic DNA Translation: CXN91953.1
LALJ01000010 Genomic DNA Translation: KMR36787.1
LALQ01000048 Genomic DNA Translation: KMR56435.1
RefSeqiWP_000273356.1, NZ_PQWV01000006.1

Genome annotation databases

EnsemblBacteriaiCFG07304; CFG07304; ERS093009_02316
CXE77994; CXE77994; ERS074020_01889
CXM25007; CXM25007; ERS072738_01928
CXN91953; CXN91953; ERS072840_01851
CXT33606; CXT33606; ERS073147_01795
CYD40889; CYD40889; ERS073767_02050
CZQ30320; CZQ30320; ERS1058648_01983
OAP74096; OAP74096; A4U86_07125
SCR61047; SCR61047; SAMEA2298760_02239
KEGGisams:NI36_10400
PATRICifig|1280.10758.peg.1900

Similar proteinsi

Entry informationi

Entry nameiQ0H0G9_STAAU
AccessioniPrimary (citable) accession number: Q0H0G9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

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