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Q0H0G9

- Q0H0G9_STAAU

UniProt

Q0H0G9 - Q0H0G9_STAAU

Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotationImported
    Metal bindingi148 – 1481ZincUniRule annotationImported
    Metal bindingi183 – 1831ZincUniRule annotationImported
    Metal bindingi186 – 1861ZincUniRule annotation
    Metal bindingi186 – 1861Zinc; via pros nitrogenImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPUniRule annotation
    Nucleotide bindingi88 – 914ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotationImported, Nucleotide-binding, ZincUniRule annotationSAAS annotationImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    ORF Names:EX97_10880Imported, SAXN108_2364Imported, X998_2098Imported
    OrganismiStaphylococcus aureusImported
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ0H0G9.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3E2IX-ray2.01A1-199[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ0H0G9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0H0G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY    50
    HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI 100
    VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS 150
    SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL 199
    Length:199
    Mass (Da):22,214
    Last modified:October 3, 2006 - v1
    Checksum:iC1EC76B7C5645909
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ384605 Genomic DNA. Translation: ABD37699.1.
    CP007539 Genomic DNA. Translation: AHW68308.1.
    CP007690 Genomic DNA. Translation: AIA28613.1.
    CP007447 Genomic DNA. Translation: AID40805.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ384605 Genomic DNA. Translation: ABD37699.1 .
    CP007539 Genomic DNA. Translation: AHW68308.1 .
    CP007690 Genomic DNA. Translation: AIA28613.1 .
    CP007447 Genomic DNA. Translation: AID40805.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3E2I X-ray 2.01 A 1-199 [» ]
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q0H0G9.
    ChEMBLi CHEMBL5323.

    Proteomic databases

    PRIDEi Q0H0G9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q0H0G9.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bacterial deoxyribonucleoside kinases."
      Sandrini M.P.B., Clausen A.R., Piskur J.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DVI CCM 885Imported.
    2. "Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria."
      Sandrini M.P., Shannon O., Clausen A.R., Bjorck L., Piskur J.
      Antimicrob. Agents Chemother. 51:2726-2732(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DVI CCM 885Imported.
    3. "Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner."
      Sandrini M.P., Clausen A.R., On S.L., Aarestrup F.M., Munch-Petersen B., Piskur J.
      J. Antimicrob. Chemother. 60:510-520(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DVI CCM 885Imported.
    4. "Crystal structure of Thymidine Kinase from S. aureus."
      Lam R., Johns K., Battaile K.P., Romanov V., Lam K., Pai E.F., Chirgadze N.Y.
      Submitted (AUG-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) IN COMPLEX WITH ZINC.
    5. "First report of a sequence type 239 vancomycin-intermediate Staphylococcus aureus isolate in Mainland China."
      Zhang X., Hu Q., Yuan W., Shang W., Cheng H., Yuan J., Zhu J., Hu Z., Li S., Chen W., Hu X., Rao X.
      Diagn. Microbiol. Infect. Dis. 77:64-68(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: XN108Imported.
    6. "Genome sequence of Staphylococcus aureus NRS 100."
      Sichtig H., Utter B., Tallon L.J., Deshong S.Lisa., Sengamalay N., Nagaraj S., McCracken C.L., Daugherty S.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NRS 100Imported.
    7. "Complete genome sequences of two prolific biofilm forming Staphylococcus aureus isolates, belonging to EMRSA15 and USA300 clonal lineages."
      Sabirova J., Britto Xavier B., Goossens H., Malhotra-Kumar S.
      Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UA-S391_USA300Imported.
    8. Zhang X., Rao X.
      Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: XN108Imported.

    Entry informationi

    Entry nameiQ0H0G9_STAAU
    AccessioniPrimary (citable) accession number: Q0H0G9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3