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Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotationCombined sources1
Metal bindingi148ZincUniRule annotationCombined sources1
Metal bindingi183ZincUniRule annotationCombined sources1
Metal bindingi186ZincUniRule annotation1
Metal bindingi186Zinc; via pros nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotationCombined sources, Nucleotide-binding, ZincUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:AYM28_11800Imported, AYM37_11800Imported, ERS072738_01928Imported, ERS072840_01851Imported, ERS073071_01667Imported, ERS073583_01719Imported, ERS074020_01889Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000071995 Componenti: Unassembled WGS sequence
  • UP000188815 Componenti: Chromosome
  • UP000072664 Componenti: Unassembled WGS sequence
  • UP000187819 Componenti: Unassembled WGS sequence
  • UP000189034 Componenti: Chromosome
  • UP000187748 Componenti: Unassembled WGS sequence
  • UP000069800 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5323.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E2IX-ray2.01A1-199[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0H0G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY
60 70 80 90 100
HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI
110 120 130 140 150
VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS
160 170 180 190
SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL
Length:199
Mass (Da):22,214
Last modified:October 3, 2006 - v1
Checksum:iC1EC76B7C5645909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ384605 Genomic DNA. Translation: ABD37699.1.
CP014415 Genomic DNA. Translation: AQR25935.1.
CP014444 Genomic DNA. Translation: AQR52454.1.
FFPZ01000009 Genomic DNA. Translation: CXE77994.1.
FGBR01000009 Genomic DNA. Translation: CXM25007.1.
FGEC01000013 Genomic DNA. Translation: CXN91953.1.
FGJX01000012 Genomic DNA. Translation: CXR95287.1.
FGWW01000011 Genomic DNA. Translation: CYA70087.1.
RefSeqiWP_000273356.1. NZ_NBZY01000022.1.

Genome annotation databases

EnsemblBacteriaiCFG07304; CFG07304; ERS093009_02316.
CXE77994; CXE77994; ERS074020_01889.
CXM25007; CXM25007; ERS072738_01928.
CXN91953; CXN91953; ERS072840_01851.
CXT33606; CXT33606; ERS073147_01795.
CYD40889; CYD40889; ERS073767_02050.
CZQ30320; CZQ30320; ERS1058648_01983.
OAP74096; OAP74096; A4U86_07125.
SCR61047; SCR61047; SAMEA2298760_02239.
GeneIDi31214852.
KEGGisams:NI36_10400.
sauf:X998_2098.
PATRICifig|1280.10758.peg.1900.

Similar proteinsi

Entry informationi

Entry nameiQ0H0G9_STAAU
AccessioniPrimary (citable) accession number: Q0H0G9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported