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Q0H0G9

- Q0H0G9_STAAU

UniProt

Q0H0G9 - Q0H0G9_STAAU

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Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotationImported
Metal bindingi148 – 1481ZincUniRule annotationImported
Metal bindingi183 – 1831ZincUniRule annotationImported
Metal bindingi186 – 1861ZincUniRule annotation
Metal bindingi186 – 1861Zinc; via pros nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:CH51_11455Imported, DP18_2475Imported, EX97_10880Imported, SAXN108_2364Imported, X998_2098Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ0H0G9.

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E2IX-ray2.01A1-199[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0H0G9.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0H0G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY
60 70 80 90 100
HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI
110 120 130 140 150
VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS
160 170 180 190
SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL
Length:199
Mass (Da):22,214
Last modified:October 3, 2006 - v1
Checksum:iC1EC76B7C5645909
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ384605 Genomic DNA. Translation: ABD37699.1.
CP007539 Genomic DNA. Translation: AHW68308.1.
CP007690 Genomic DNA. Translation: AIA28613.1.
CP007447 Genomic DNA. Translation: AID40805.1.
CP007499 Genomic DNA. Translation: AIL58624.1.
JOVN01000001 Genomic DNA. Translation: KFL14507.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ384605 Genomic DNA. Translation: ABD37699.1 .
CP007539 Genomic DNA. Translation: AHW68308.1 .
CP007690 Genomic DNA. Translation: AIA28613.1 .
CP007447 Genomic DNA. Translation: AID40805.1 .
CP007499 Genomic DNA. Translation: AIL58624.1 .
JOVN01000001 Genomic DNA. Translation: KFL14507.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3E2I X-ray 2.01 A 1-199 [» ]
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q0H0G9.
ChEMBLi CHEMBL5323.

Proteomic databases

PRIDEi Q0H0G9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q0H0G9.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bacterial deoxyribonucleoside kinases."
    Sandrini M.P.B., Clausen A.R., Piskur J.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DVI CCM 885Imported.
  2. "Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria."
    Sandrini M.P., Shannon O., Clausen A.R., Bjorck L., Piskur J.
    Antimicrob. Agents Chemother. 51:2726-2732(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DVI CCM 885Imported.
  3. "Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner."
    Sandrini M.P., Clausen A.R., On S.L., Aarestrup F.M., Munch-Petersen B., Piskur J.
    J. Antimicrob. Chemother. 60:510-520(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DVI CCM 885Imported.
  4. "Crystal structure of Thymidine Kinase from S. aureus."
    Lam R., Johns K., Battaile K.P., Romanov V., Lam K., Pai E.F., Chirgadze N.Y.
    Submitted (AUG-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) IN COMPLEX WITH ZINC.
  5. "First report of a sequence type 239 vancomycin-intermediate Staphylococcus aureus isolate in Mainland China."
    Zhang X., Hu Q., Yuan W., Shang W., Cheng H., Yuan J., Zhu J., Hu Z., Li S., Chen W., Hu X., Rao X.
    Diagn. Microbiol. Infect. Dis. 77:64-68(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: XN108Imported.
  6. "Complete Genome Sequence of Staphylococcus aureus XN108, an ST239-MRSA-SCCmec III Strain with Intermediate Vancomycin Resistance Isolated in Mainland China."
    Zhang X., Xu X., Yuan W., Hu Q., Shang W., Hu X., Tong Y., Rao X.
    Genome Announc. 2:e00449-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: XN108Imported.
  7. "Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element."
    Benson M.A., Ohneck E.A., Ryan C., Alonzo F.III., Smith H., Narechania A., Kolokotronis S.O., Satola S.W., Uhlemann A.C., Sebra R., Deikus G., Shopsin B., Planet P.J., Torres V.J.
    Mol. Microbiol. 93:664-681(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2395 USA500Imported.
  8. "Genome sequence of Staphylococcus aureus NRS 100."
    Sichtig H., Utter B., Tallon L.J., Deshong S.Lisa., Sengamalay N., Nagaraj S., McCracken C.L., Daugherty S.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRS 100Imported.
  9. "Complete genome sequences of two prolific biofilm forming Staphylococcus aureus isolates, belonging to EMRSA15 and USA300 clonal lineages."
    Sabirova J., Britto Xavier B., Goossens H., Malhotra-Kumar S.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UA-S391_USA300Imported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CDC 73-57501Imported.

Entry informationi

Entry nameiQ0H0G9_STAAU
AccessioniPrimary (citable) accession number: Q0H0G9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3