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Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotationCombined sources1
Metal bindingi148ZincUniRule annotationCombined sources1
Metal bindingi183ZincUniRule annotationCombined sources1
Metal bindingi186ZincUniRule annotation1
Metal bindingi186Zinc; via pros nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationCombined sources, Nucleotide-binding, ZincUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:A4U86_07125Imported, A7J36_00175Imported, ERS072738_01928Imported, ERS072840_01851Imported, ERS073147_01795Imported, ERS073767_02050Imported, ERS074020_01889Imported, ERS1058648_01983Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000077578 Componenti: Unassembled WGS sequence
  • UP000071995 Componenti: Unassembled WGS sequence
  • UP000072664 Componenti: Unassembled WGS sequence
  • UP000074953 Componenti: Unassembled WGS sequence
  • UP000078523 Componenti: Unassembled WGS sequence
  • UP000073331 Componenti: Unassembled WGS sequence
  • UP000075156 Componenti: Unassembled WGS sequence
  • UP000069800 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5323.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi93062.SACOL2111.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E2IX-ray2.01A1-199[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0H0G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY
60 70 80 90 100
HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI
110 120 130 140 150
VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS
160 170 180 190
SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL
Length:199
Mass (Da):22,214
Last modified:October 3, 2006 - v1
Checksum:iC1EC76B7C5645909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ384605 Genomic DNA. Translation: ABD37699.1.
FFPZ01000009 Genomic DNA. Translation: CXE77994.1.
FGBR01000009 Genomic DNA. Translation: CXM25007.1.
FGEC01000013 Genomic DNA. Translation: CXN91953.1.
FGLU01000010 Genomic DNA. Translation: CXT33606.1.
FHAW01000012 Genomic DNA. Translation: CYD40889.1.
FJMW01000008 Genomic DNA. Translation: CZQ30320.1.
LXNN01000001 Genomic DNA. Translation: OAF75094.1.
LWAL01000077 Genomic DNA. Translation: OAP74096.1.
RefSeqiWP_000273356.1. NZ_MCFM01000006.1.

Genome annotation databases

EnsemblBacteriaiAIL58624; AIL58624; CH51_11455.
CEK45138; CEK45138; SASCBU26_02125.
CFG07304; CFG07304; ERS093009_02316.
CFO15780; CFO15780; ERS179246_00399.
COY32565; COY32565; ERS195423_02067.
CPC08466; CPC08466; ERS092844_02291.
CUD32253; CUD32253; ERS365775_02415.
CUE37441; CUE37441; ERS410449_02287.
CUF81904; CUF81904; ERS411017_02570.
CUG00077; CUG00077; ERS411009_02499.
KLN10997; KLN10997; RL02_00660.
KMY71052; KMY71052; TM61_09115.
KQB70252; KQB70252; AL077_08825.
GeneIDi28380295.
KEGGisauf:X998_2098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ384605 Genomic DNA. Translation: ABD37699.1.
FFPZ01000009 Genomic DNA. Translation: CXE77994.1.
FGBR01000009 Genomic DNA. Translation: CXM25007.1.
FGEC01000013 Genomic DNA. Translation: CXN91953.1.
FGLU01000010 Genomic DNA. Translation: CXT33606.1.
FHAW01000012 Genomic DNA. Translation: CYD40889.1.
FJMW01000008 Genomic DNA. Translation: CZQ30320.1.
LXNN01000001 Genomic DNA. Translation: OAF75094.1.
LWAL01000077 Genomic DNA. Translation: OAP74096.1.
RefSeqiWP_000273356.1. NZ_MCFM01000006.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E2IX-ray2.01A1-199[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2111.

Chemistry databases

ChEMBLiCHEMBL5323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIL58624; AIL58624; CH51_11455.
CEK45138; CEK45138; SASCBU26_02125.
CFG07304; CFG07304; ERS093009_02316.
CFO15780; CFO15780; ERS179246_00399.
COY32565; COY32565; ERS195423_02067.
CPC08466; CPC08466; ERS092844_02291.
CUD32253; CUD32253; ERS365775_02415.
CUE37441; CUE37441; ERS410449_02287.
CUF81904; CUF81904; ERS411017_02570.
CUG00077; CUG00077; ERS411009_02499.
KLN10997; KLN10997; RL02_00660.
KMY71052; KMY71052; TM61_09115.
KQB70252; KQB70252; AL077_08825.
GeneIDi28380295.
KEGGisauf:X998_2098.

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0H0G9_STAAU
AccessioniPrimary (citable) accession number: Q0H0G9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.