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Protein

Potassium channel toxin Tdi-beta-KTx

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks voltage-gated potassium channels.By similarity

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin Tdi-beta-KTx
Short name:
TdibetaKTx
OrganismiTityus discrepans (Venezuelan scorpion)
Taxonomic identifieri57059 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000027467620 – 271 Publication8
ChainiPRO_000027467728 – 87Potassium channel toxin Tdi-beta-KTxAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 77By similarity
Disulfide bondi63 ↔ 82By similarity
Disulfide bondi67 ↔ 84By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiQ0GY44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR029237. Long_scorpion_toxin.
IPR003614. Scorpion_toxin-like.
PfamiView protein in Pfam
PF14866. Toxin_38. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0GY44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKLALLLL LGMITLASSG LREKHVQKLV TLIPNDTLRS IMKTIVHKLA
60 70 80
KTQFGCPAYE GYCMNHCQDI ERHDGSCHGF KCKCEKS
Length:87
Mass (Da):9,833
Last modified:October 3, 2006 - v1
Checksum:iC0A6323AF4BF0372
GO

Mass spectrometryi

Molecular mass is 6822.6 Da from positions 28 - 87. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ465347 mRNA. Translation: ABE98263.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKBX1_TITDI
AccessioniPrimary (citable) accession number: Q0GY44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 3, 2006
Last modified: May 10, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families