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Q0GY44 (KBX1_TITDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin Tdi-beta-KTx

Short name=TdibetaKTx
OrganismTityus discrepans (Venezuelan scorpion)
Taxonomic identifier57059 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks voltage-gated potassium channels By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Mass spectrometry

Molecular mass is 6822.6 Da from positions 28 - 87. Determined by MALDI. Ref.3

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 278
PRO_0000274676
Chain28 – 8760Potassium channel toxin Tdi-beta-KTx
PRO_0000274677

Amino acid modifications

Disulfide bond56 ↔ 77 By similarity
Disulfide bond63 ↔ 82 By similarity
Disulfide bond67 ↔ 84 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0GY44 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: C0A6323AF4BF0372

FASTA879,833
        10         20         30         40         50         60 
MERKLALLLL LGMITLASSG LREKHVQKLV TLIPNDTLRS IMKTIVHKLA KTQFGCPAYE 

        70         80 
GYCMNHCQDI ERHDGSCHGF KCKCEKS 

« Hide

References

[1]"Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
Peptides 28:31-37(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-74.
Tissue: Venom and Venom gland.
[2]"Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans."
D'Suze G., Schwartz E.F., Garcia-Gomez B.I., Sevcik C., Possani L.D.
Biochimie 91:1010-1019(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[3]"Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins."
Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D.
Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ465347 mRNA. Translation: ABE98263.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKBX1_TITDI
AccessionPrimary (citable) accession number: Q0GY44
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries