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Q0GY44

- KBX1_TITDI

UniProt

Q0GY44 - KBX1_TITDI

Protein

Potassium channel toxin Tdi-beta-KTx

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks voltage-gated potassium channels.By similarity

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin Tdi-beta-KTx
    Short name:
    TdibetaKTx
    OrganismiTityus discrepans (Venezuelan scorpion)
    Taxonomic identifieri57059 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 2781 PublicationPRO_0000274676
    Chaini28 – 8760Potassium channel toxin Tdi-beta-KTxPRO_0000274677Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 77By similarity
    Disulfide bondi63 ↔ 82By similarity
    Disulfide bondi67 ↔ 84By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0GY44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKLALLLL LGMITLASSG LREKHVQKLV TLIPNDTLRS IMKTIVHKLA   50
    KTQFGCPAYE GYCMNHCQDI ERHDGSCHGF KCKCEKS 87
    Length:87
    Mass (Da):9,833
    Last modified:October 3, 2006 - v1
    Checksum:iC0A6323AF4BF0372
    GO

    Mass spectrometryi

    Molecular mass is 6822.6 Da from positions 28 - 87. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ465347 mRNA. Translation: ABE98263.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ465347 mRNA. Translation: ABE98263.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
      Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
      Peptides 28:31-37(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-74.
      Tissue: Venom and Venom gland.
    2. "Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans."
      D'Suze G., Schwartz E.F., Garcia-Gomez B.I., Sevcik C., Possani L.D.
      Biochimie 91:1010-1019(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.
    3. "Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins."
      Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D.
      Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKBX1_TITDI
    AccessioniPrimary (citable) accession number: Q0GY44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3